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The Joneses were referred to a clinical geneticist because their 6-month-old daughter was failing to grow adequately and was having recurrent infections. The geneticist took a detailed family history (which was uninformative) and a medical history of their daughter. He discovered that their daughter had a history of a constant cough and wheeze that was becoming progressively worse, had difficulty gaining weight (failure to thrive), and had an extensive history of yeast infection (thrush) in her mouth. The geneticist did a simple blood test to check their daughter’s white blood count and determined that she had severe combined immunodeficiency (SCID).
The geneticist explained that SCID is an immune deficiency that causes a marked susceptibility to infections. The defining characteristic is usually a severe defect in both the T- and B-lymphocyte systems. This results in one or more infections within the first few months of life that are serious and may even be life-threatening. Based on the family history, it was possible that their daughter had inherited a mutant allele from each of them and therefore was homozygous for a gene that causes SCID. If so, each time the Joneses had a child, there would be a 25% chance that the child would have SCID. Prenatal testing is available to determine whether the developing fetus has SCID.
If the Joneses want to be certain that their next child will not have SCID, what types of reproductive options do you think they have?
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Chapter 17 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
- A couple has had a child born with neurofibromatosis. They come to your genetic counseling office for help. After taking an extensive family history, you determine that there is no history of this disease on either side of the family. The couple wants to have another child and wants to be advised about the risks of that child having neurofibromatosis. What advice do you give them?arrow_forwardI have provided everything needed please help me outarrow_forwardA 22-year-old man enters the clinic with a wide-stepping gait, muscle wasting, myotonia, and bilateral cataracts. His father, who is 55, currently suffers from similar symptoms, which began about 5 years ago. His father's sister also exhibits similar symptoms; hers also began in her 50s. The patient's mother exhibits none of these symptoms. What is the inheritance pattern of this patient's most likely disease?arrow_forward
- Please help me answer Part III- 1, 2, 3, 4 of this case study, Thank you, Heres a link to the PDF https://www.cusd80.com/cms/lib/AZ01001175/Centricity/Domain/8922/eofad.pdfarrow_forwardWhat is the sequence of the sister and the patient?Were you able to identify the mutation?arrow_forwardWhat cause of the genetic disease site your sources provide links to the websites to use?arrow_forward
- Three people are diagnosed with different types of cancer. One is a lifelong smoker and has lung cancer, one has active Crohn disease and colorectal cancer, and the other is a farmer with newly diagnosed melanoma. What do these individuals have in common?arrow_forwardJeremy notices that his friend Dan (the son of Robyn, a single parent) has the same laugh and dimples as the longtime mailman. Ignoring ethical and privacy concerns, Jeremy decides that since he has just learned about PCR in class, he will perform a paternity test on the side during his BISC 336 lab to determine whether Mike is related to the mailman or whether he is related to the Corner store clerk. He obtains hair samples from all three. He finds a 100% match between Mike and the mailman, what should he tell Mike? A. He found his long lost Father - the milkman B. Nothing, it is impolite to meddle is someone else's business C. Nothing he can't determine relatives using the information he has D. He found his long lost Father - the milkman E. Nothing, instead he should contact the news media and tell them he has found the first cloned humanarrow_forwardI need the answer as soon as possiblearrow_forward
- Cystic fibrosis (CF) is an autosomal recessive trait (a). Assume that Emily (who has CF) decides to have children with a man who does not have CF and who is not a carrier of CF. What are their genotypes, and what is the probability that they will have a child who is a carrier for CF?arrow_forwardJanet has been having some abdominal pains lately and is of an Ashkanazi Jewish decent. What may be happening to her based on her genetics?arrow_forwardPlease help me draw the pedigree analysis of the given problem together with the b-c questions. Thank you so much! I really appreciate it.arrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
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