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2. A reversion is a mutation that returns a mutant codon back to a codon that gives a wild-type phenotype. At the DNA level, this type of mutation can be an exact reversion or an equivalent reversion. GAG First GTG Exact GAG (glutamic acid) mutation (valine) reversion (glutamic acid) GAG - GTG First Equivalent (valine) reversion GAA (glutamic acid) mutation (glutamic acid) GAG First GTG Equivalent - GAT (glutamic acid) mutation (valine) reversion (aspartic acid) An equivalent reversion produces a protein that is equivalent to the wild type in structure and function. This can occur in two ways. In some cases, the reversion produces the wild-type amino acid (in this case, glutamic acid), but it uses a different codon than the wild-type gene. Alternatively. an equivalent reversion may substitute an amino acid structurally similar to the wild-type amino acid. In our example, an equivalent reversion has changed valine to an aspartic acid. Because aspartic and glutamic acids are structurally similar-they are acidic amino acids-this type of reversion can restore wild-type structure and function. Now here is the question. The template strand within the coding sequence of a gene has the following sequence: 3'-TACCCCTTCGACCCCGGA-5' This template produces the following mRNA: 5'-AUGGGGAAGCUGGGGCCA–3' The MRNA encodes a polypeptide with the following sequence: methionine-glycine-lysine–leucine-glycine-proline. A mutation changes the template strand to this sequence: 3'-TACCCCTACGACCCCGGA-5' After the first mutation, another mutation occurs to change this sequence again. Is each of the following second mutations an exact reversion, an equivalent reversion, or neither? 3'-TACCCCTCCGACCCCGGA-5' 3'-TACCCCTTCGACCCCGGA-5' 3'-TACCCCGACGACCCCGGA-5'

2. A reversion is a mutation that returns a mutant codon back to a codon that gives a wild-type phenotype. At the DNA level, this type of mutation can be an exact reversion or an equivalent reversion. GAG First GTG Exact GAG (glutamic acid) mutation (valine) reversion (glutamic acid) GAG - GTG First Equivalent (valine) reversion GAA (glutamic acid) mutation (glutamic acid) GAG First GTG Equivalent - GAT (glutamic acid) mutation (valine) reversion (aspartic acid) An equivalent reversion produces a protein that is equivalent to the wild type in structure and function. This can occur in two ways. In some cases, the reversion produces the wild-type amino acid (in this case, glutamic acid), but it uses a different codon than the wild-type gene. Alternatively. an equivalent reversion may substitute an amino acid structurally similar to the wild-type amino acid. In our example, an equivalent reversion has changed valine to an aspartic acid. Because aspartic and glutamic acids are structurally similar-they are acidic amino acids-this type of reversion can restore wild-type structure and function. Now here is the question. The template strand within the coding sequence of a gene has the following sequence: 3'-TACCCCTTCGACCCCGGA-5' This template produces the following mRNA: 5'-AUGGGGAAGCUGGGGCCA–3' The MRNA encodes a polypeptide with the following sequence: methionine-glycine-lysine–leucine-glycine-proline. A mutation changes the template strand to this sequence: 3'-TACCCCTACGACCCCGGA-5' After the first mutation, another mutation occurs to change this sequence again. Is each of the following second mutations an exact reversion, an equivalent reversion, or neither? 3'-TACCCCTCCGACCCCGGA-5' 3'-TACCCCTTCGACCCCGGA-5' 3'-TACCCCGACGACCCCGGA-5'

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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2. A reversion is a mutation that returns a mutant codon back to a codon that gives a wild-type phenotype. At the DNA level, this type of mutation can be an exact reversion or an equivalent reversion. GAG First GTG Exact GAG (glutamic acid) mutation (valine) reversion (glutamic acid) GAG - GTG First Equivalent (valine) reversion GAA (glutamic acid) mutation (glutamic acid) GAG First GTG Equivalent - GAT (glutamic acid) mutation (valine) reversion (aspartic acid) An equivalent reversion produces a protein that is equivalent to the wild type in structure and function. This can occur in two ways. In some cases, the reversion produces the wild-type amino acid (in this case, glutamic acid), but it uses a different codon than the wild-type gene. Alternatively. an equivalent reversion may substitute an amino acid structurally similar to the wild-type amino acid. In our example, an equivalent reversion has changed valine to an aspartic acid. Because aspartic and glutamic acids are structurally similar-they are acidic amino acids-this type of reversion can restore wild-type structure and function. Now here is the question. The template strand within the coding sequence of a gene has the following sequence: 3'-TACCCCTTCGACCCCGGA-5' This template produces the following mRNA: 5'-AUGGGGAAGCUGGGGCCA–3' The MRNA encodes a polypeptide with the following sequence: methionine-glycine-lysine–leucine-glycine-proline. A mutation changes the template strand to this sequence: 3'-TACCCCTACGACCCCGGA-5'
Transcribed Image Text:2. A reversion is a mutation that returns a mutant codon back to a codon that gives a wild-type phenotype. At the DNA level, this type of mutation can be an exact reversion or an equivalent reversion. GAG First GTG Exact GAG (glutamic acid) mutation (valine) reversion (glutamic acid) GAG - GTG First Equivalent (valine) reversion GAA (glutamic acid) mutation (glutamic acid) GAG First GTG Equivalent - GAT (glutamic acid) mutation (valine) reversion (aspartic acid) An equivalent reversion produces a protein that is equivalent to the wild type in structure and function. This can occur in two ways. In some cases, the reversion produces the wild-type amino acid (in this case, glutamic acid), but it uses a different codon than the wild-type gene. Alternatively. an equivalent reversion may substitute an amino acid structurally similar to the wild-type amino acid. In our example, an equivalent reversion has changed valine to an aspartic acid. Because aspartic and glutamic acids are structurally similar-they are acidic amino acids-this type of reversion can restore wild-type structure and function. Now here is the question. The template strand within the coding sequence of a gene has the following sequence: 3'-TACCCCTTCGACCCCGGA-5' This template produces the following mRNA: 5'-AUGGGGAAGCUGGGGCCA–3' The MRNA encodes a polypeptide with the following sequence: methionine-glycine-lysine–leucine-glycine-proline. A mutation changes the template strand to this sequence: 3'-TACCCCTACGACCCCGGA-5'
After the first mutation, another mutation occurs to change this sequence again. Is each of the following second mutations an exact reversion, an equivalent reversion, or neither? 3'-TACCCCTCCGACCCCGGA-5' 3'-TACCCCTTCGACCCCGGA-5' 3'-TACCCCGACGACCCCGGA-5'
Transcribed Image Text:After the first mutation, another mutation occurs to change this sequence again. Is each of the following second mutations an exact reversion, an equivalent reversion, or neither? 3'-TACCCCTCCGACCCCGGA-5' 3'-TACCCCTTCGACCCCGGA-5' 3'-TACCCCGACGACCCCGGA-5'
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