Biology (MindTap Course List)
Biology (MindTap Course List)
11th Edition
ISBN: 9781337392938
Author: Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher: Cengage Learning
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Chapter 8, Problem 17TYU

EVOLUTION LINK The reactions of glycolysis are identical in all organisms—prokaryotes, protists, fungi, plants, and animals—that obtain energy from glucose catabolism. What does this universality suggest about the evolution of glycolysis?

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While the conversion of glucose (Glc) to pyrucate (Pyr) is shared across all domains of life, the route to get there can differ dramatically. In some Archaea, for example, some of the key steps in glycolysis differ. One example of this is the conversion of glyceraldehyde 3-phosphate (GAP) to 3-phosphoglycerate (3PG). Instead of the two-step process catalyzed by GAPDH and PGK:                             GAPDH GAP + Pi + NAD+ -----> BGP + NADH                                                                    PGK                                             BGP + ADP <-----> 3PG + ATP The archaeal pathway utilizes the enzyme non-phosporylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) to catalyze the metabolically irreversible step shown below:                         GAPN GAP + NADP+ ---> BGP + NADPH   In bacteria and eukaryotes, GAPDH/PGK are not regulated via allosteric activation or inhibition. Do you imagine this is the same for GAPN? Why or why not?
While the conversion of glucose (Glc) to pyrucate (Pyr) is shared across all domains of life, the route to get there can differ dramatically. In some Archaea, for example, some of the key steps in glycolysis differ. One example of this is the conversion of glyceraldehyde 3-phosphate (GAP) to 3-phosphoglycerate (3PG). Instead of the two-step process catalyzed by GAPDH and PGK:                             GAPDH GAP + Pi + NAD+ -----> BGP + NADH                                                                    PGK                                             BGP + ADP <-----> 3PG + ATP The archaeal pathway utilizes the enzyme non-phosporylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) to catalyze the metabolically irreversible step shown below:                         GAPN GAP + NADP+ ---> BGP + NADPH In terms of the ΔGrxn, why is the GAPDH+PGK process reversible but the GAPN process is not?
The citric acid cycle functions to completely oxidize glucose in the presence of oxygen, allowing for a large amount of ATP to be produced within the cell through oxidative phosphorylation. Free oxygen did not always exist within the atmosphere of Earth, meaning that early life forms relied solely on glycolysis and fermentation to extract energy from macromolecules. What role did the increase in atmospheric oxygen play in the evolution of life on Earth? Frame your answer in terms of the energy derived from cellular respiration in the presence and absence of oxygen.

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Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY