Organic Chemistry
Organic Chemistry
12th Edition
ISBN: 9781118875766
Author: T. W. Graham Solomons, Craig B. Fryhle, Scott A. Snyder
Publisher: WILEY
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Chapter 5, Problem 1LGP
Interpretation Introduction

Interpretation:

All the chiral centers in the structure of streptomycin are to be identified and the appropriate (R) or (S) designation for the configuration of each chirality center in it is to be determined.

Concept introduction:

Each center is analyzed separately if the compound contains more than one chirality center.

The designation of each carbon is determined by using numbers.

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Coibacin B (shown below) is a natural product that exhibits potent anti-inflammatory activity and potential activity in the treatment of leishmaniasis, a disease caused by certain parasites (Org. Lett. 2012, 14, 3878-3881): (a) Assign the configuration (R or S) of each chirality center (labeled A to C) in coibacin B. (b) Identify the number of possible stereoisomers for this compound, assuming that the geometry of the alkenes are fixed. Choices are given below and write the CAPITAL LETTER of your choice. A. 2 В. 4 С. 8 D. 16 ANSWERS: (a) A. В. C. (b)
Why are some chiral drugs are sold as a mixture of enantiomers and why some are not? How enantiomers affect the biological activity of the drugs? Explain.
can you please add an explanation.

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Organic Chemistry

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