Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 45, Problem 13TYK
Summary Introduction

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Myasthenia gravis, an autoimmune disease, may develop into cats, dogs, and humans. Individuals suffering with the disease experience severe fatigue with even small levels of exertion, drooping of facial muscles, and trouble keeping their eyelids open.

Introduction:

Myasthenia gravis is a neuromuscular type of autoimmune disease. Autoimmune disease is a medical condition in which antibodies are formed against self-molecules in the cell, mostly against the receptors. The antibodies are formed against acetylcholine receptors in the synapse of neurons and muscle cells.

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A nerve conduction velocity test measures nerve conduction velocity. In this test, an electrical stimulus is applied to a peripheral nerve and the length of time it takes for the corresponding muscle to contract is measured. Because the length of the nerve from stimulus point to muscle and the time it takes for the muscle to contract are both known, NCV can be calculated. This test result is helpful in distinguishing between different types of pathologies. For example, a patient with muscle weakness is being tested by a physician. There are three possible sources of the weakness: Disease of the muscle itself such as muscular dystrophy. In this condition, normal muscle tissue is replaced by adipose tissue and the muscle becomes incapable of contraction. Disease at the neuromuscular junction (NMJ) such as myasthenia gravis. This condition is described in the Skeletal Muscle Histology exercise and results from damage to the acetylcholine receptors on the muscle end plate. Disease…
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