Concept explainers
To discuss:
How alternative splicing partially explains the diversity of human protein that exceeds the number of human genes.
Introduction:
DNA is a genetic material consisting of a long stretch of
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Anatomy & Physiology: The Unity of Form and Function
- The relationship between the nucleotide sequence of an mRNA and the DNA strand from which it is transcribed. Messenger RNAs are synthesized by RNA polymerases that read along a DNA template strand in the 3'→5' direction, polymerizing ribonucleotides in the 5'→3' direction. Give the nucleotide sequence (5'→3') of the DNA template strand from which the following mRNA segment was transcribed: 5'-UAG UGA CAG UUG CGAU-3’arrow_forwardPromoters of the INS genearrow_forwardGive typing answer with explanation and conclusionarrow_forward
- The three stages of transcription (initiation, elongation, and termination) – with a focus on how RNA Polymerase II (Pol II) relates to these stages. The final product of transcriptionarrow_forwardReading frame Frameshift Initiation factors Elongation factors. Release factors E III III III III Proteins that bind to a nonsense codon on mRNA and halt translation. Tagging defective proteins with 3 or more ubiquitins will target it for destruction. Destroys defective proteins that have been polyubiquitinated. A reversion of a mutant back to wild type function. A mutation such as an indel that shifts the triplet reading frame to a different series of nucleotides altering every downstream codon from that point onward. Open in Parrow_forwardHow many tRNA molecules can associate with a ribosome at any given time during translationarrow_forward
- One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain and other severe complications. What is the name of the process in which each peptide is actually assembled, and where does this process take place? transcription, on ribosomes translation, in the nucleus translation, on ribosomes transcription, in the nucleusarrow_forwardTyped explanation only Codons in mRNA molecule and their corresponding amino acids UUU Phenylalanine UAU tyrosine UUA leucine UAA nonsense GCA alanine AAU asparagine AAG lysine UGC cysteine GUU valine UCG, UCU serine Refer to Table 8.2. If the sequence of amino acids encoded by a strand of DNA is serine-alanine-lysine-leucine, what is the order of bases in the sense strand of DNA? Group of answer choices 5' TGTGCTTTCTTA 3' 3' AGACGTTTCAAT 5' 3' UGUGCAAAGUUA 5' 5' AGAGCTTTGAAT 3' 3' TCTCGTTTGTTA 5'arrow_forwardthe relationship between mutation of RECQ5 and human disease, in particular exploring the effects on protein structure, function and interaction.arrow_forward
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning