The pro-R or pro-S hydrogen removed from citrate during the dehydration in step 2 of the citric acid cycle. Concept introduction: A molecule is said to be pro chiral, if it can be converted from achiral to chiral a single chemical step. For instance, an unsymmetrical ketone like 2-butanone is pro chiral because it can be converted to the chiral alcohol 2-butanol, by the addition of hydrogen. Which enantiomer of 2-butanol is produced depends on which face of the planar carbonyl undergoes reaction to distinguish between the possibilities, the stereo chemical description Re and Si (announced ‘ray’ and ‘sigh’) are used. The concept of this designation is as follows: Rank the three groups attached to the trigonal, sp 2 hybridized carbon according to the conventional Cahn-In gold-Prelog (CIP) system and imagine curved among from the highest to second highest, to third highest ranked substituents.

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rivatives: Nucleophilic Acyl Substitution Reactions - EOC O C-O [References] One step in the gluconeogenesis pathway for the biosynthesis of glucose is the partial reduction of 3-phosphoglycerate to give glyceraldehyde 3-phosphate. The process occurs by phosphorylation with ATP to give 1,3-bisphosphoglycerate, reaction with a thiol group on the enzyme to give an enzyme-bound thioester, and reduction with NADH. H-C-OH ATP ADP CH₂OPO32- 3-phosphoglycerate 0= OPO32- C H-C-OH CH₂OPO32 1,3-bisphosphoglycerate Enz-SH PO43- O= C S-Enz H-C-OH CH₂OPO3² (Enzyme-bound thioester) NADH/H+ O=C NAD*, Enz-SH H H-C-OH CH₂OPO3²- glyceraldehyde 3-phosphate Propose a structure for the first intermediate in the reaction of the enzyme-bound thioester with NADH to form glyceraldehyde 3-phosphate. To simplify the drawing process, substitute the structure below for the enzyme-bound thioester. S-CH3 substitute for the CH2CH3 enzyme-bound thioester You do not have to consider stereochemistry. • You do not have…

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Question

Chapter 29.7, Problem 12P

Interpretation Introduction

Interpretation:

The pro-R or pro-S hydrogen removed from citrate during the dehydration in step 2 of the citric acid cycle.

Concept introduction:

A molecule is said to be pro chiral, if it can be converted from achiral to chiral a single chemical step.

For instance, an unsymmetrical ketone like 2-butanone is pro chiral because it can be converted to the chiral alcohol 2-butanol, by the addition of hydrogen.

Which enantiomer of 2-butanol is produced depends on which face of the planar carbonyl undergoes reaction to distinguish between the possibilities, the stereo chemical description Re and Si (announced ‘ray’ and ‘sigh’) are used.

The concept of this designation is as follows: Rank the three groups attached to the trigonal, sp² hybridized carbon according to the conventional Cahn-In gold-Prelog (CIP) system and imagine curved among from the highest to second highest, to third highest ranked substituents.

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rivatives: Nucleophilic Acyl Substitution Reactions - EOC O C-O [References] One step in the gluconeogenesis pathway for the biosynthesis of glucose is the partial reduction of 3-phosphoglycerate to give glyceraldehyde 3-phosphate. The process occurs by phosphorylation with ATP to give 1,3-bisphosphoglycerate, reaction with a thiol group on the enzyme to give an enzyme-bound thioester, and reduction with NADH. H-C-OH ATP ADP CH₂OPO32- 3-phosphoglycerate 0= OPO32- C H-C-OH CH₂OPO32 1,3-bisphosphoglycerate Enz-SH PO43- O= C S-Enz H-C-OH CH₂OPO3² (Enzyme-bound thioester) NADH/H+ O=C NAD*, Enz-SH H H-C-OH CH₂OPO3²- glyceraldehyde 3-phosphate Propose a structure for the first intermediate in the reaction of the enzyme-bound thioester with NADH to form glyceraldehyde 3-phosphate. To simplify the drawing process, substitute the structure below for the enzyme-bound thioester. S-CH3 substitute for the CH2CH3 enzyme-bound thioester You do not have to consider stereochemistry. • You do not have…

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