It should be determined that how is hormone binding to its receptor more like an allosteric regulator binding to an enzyme than a substrate binding to an enzyme. Concept Introduction: Hormones are chemical substances synthesized in small amounts by endocrine tissues and carried by blood stream to another tissue, where it acts as a messenger to regulate the function of the target tissue or organ. A given hormone usually affects only a limited number of cells, which are called target cells and it responds to a hormone because it bears receptors for the hormone. Enzymes are proteins that increase the rate of reaction by lowering the energy of activation and so they are known as “biological catalysts” Allosteric (means “other site”) enzymes have two receptor sites in which one site fits the substrate like other enzymes and the other site fits an inhibitor or activator molecule. Secondary messengers are short lived intracellular signaling molecules. Elevated concentration of these types of messengers leads to rapid alteration in the activity of one or more cellular enzymes.

Question

Want to see the full answer?

Answer 1

Question

Chapter 28, Problem 28.27AP

Interpretation Introduction

Interpretation:

It should be determined that how is hormone binding to its receptor more like an allosteric regulator binding to an enzyme than a substrate binding to an enzyme.

Concept Introduction:

Hormones are chemical substances synthesized in small amounts by endocrine tissues and carried by blood stream to another tissue, where it acts as a messenger to regulate the function of the target tissue or organ.

A given hormone usually affects only a limited number of cells, which are called target cells and it responds to a hormone because it bears receptors for the hormone.

Enzymes are proteins that increase the rate of reaction by lowering the energy of activation and so they are known as “biological catalysts”

Allosteric (means “other site”) enzymes have two receptor sites in which one site fits the substrate like other enzymes and the other site fits an inhibitor or activator molecule.

Secondary messengers are short lived intracellular signaling molecules. Elevated concentration of these types of messengers leads to rapid alteration in the activity of one or more cellular enzymes.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!