HUMAN PHYSIO W/ APR & PHILS (LL) PKG
15th Edition
ISBN: 9781265382353
Author: Fox
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 11, Problem 16bCP
Summary Introduction
To review:
The significance of the isoenzymatic forms of cyclooxygenase in the action of nonsteroidal anti-inflammatory drugs.
Introduction:
Cyclooxygenase is an enzyme which converts arachidonic acid into prostaglandin and it is also known as prostaglandin-endoperoxide synthase (PTGS). The prostaglandins are the active lipid compounds known as eicosanoids and they consist of twenty carbon skeletons. Different forms of prostaglandins regulate different functions in the body.
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Chapter 11 Solutions
HUMAN PHYSIO W/ APR & PHILS (LL) PKG
Ch. 11 - Compare the four chemical classes of hormones with...Ch. 11 - Define prohormone and prehormone, and give...Ch. 11 - Prob. 1cCPCh. 11 - Prob. 2aCPCh. 11 - Prob. 2bCPCh. 11 - Prob. 3CPCh. 11 - Prob. 4aCPCh. 11 - Describe the sequence of events by which a hormone...Ch. 11 - Prob. 4cCPCh. 11 - Prob. 5aCP
Ch. 11 - Prob. 5bCPCh. 11 - List the hormones secreted by the anterior...Ch. 11 - Prob. 7CPCh. 11 - Prob. 8aCPCh. 11 - Prob. 8bCPCh. 11 - Prob. 9aCPCh. 11 - Prob. 9bCPCh. 11 - Describe the structure of the thyroid gland and...Ch. 11 - Describe how thyroid hormones are produced and how...Ch. 11 - Prob. 10cCPCh. 11 - Describe the location of the parathyroid glands...Ch. 11 - Prob. 12aCPCh. 11 - Describe how insulin and glucagon secretion are...Ch. 11 - Prob. 13CPCh. 11 - Prob. 14CPCh. 11 - Explain the nature of autocrine regulation. How...Ch. 11 - List some of the paracrine regulators produced by...Ch. 11 - Prob. 16aCPCh. 11 - Prob. 16bCPCh. 11 - Prob. 1RACh. 11 - Prob. 2RACh. 11 - Which of these statements about the adrenal cortex...Ch. 11 - Which of these statements about the hormone...Ch. 11 - Prob. 5RACh. 11 - Prob. 6RACh. 11 - Prob. 7RACh. 11 - Prob. 8RACh. 11 - Steroid hormones arc secreted by...Ch. 11 - Prob. 10RACh. 11 - Prob. 11RACh. 11 - Prob. 12RACh. 11 - Prob. 13RACh. 11 - Which of these hormones may have a primary role in...Ch. 11 - Prob. 15RACh. 11 - What do insulin-like growth factors,...Ch. 11 - Prob. 17RACh. 11 - Prob. 18RACh. 11 - Prob. 19RACh. 11 - Describe the sequence of events by which a hormone...Ch. 11 - Prob. 21RACh. 11 - Prob. 22RACh. 11 - Prob. 23RACh. 11 - Prob. 24RACh. 11 - Describe how thyroid hormone secretion is...Ch. 11 - Prob. 26RACh. 11 - Prob. 27RACh. 11 - Prob. 28RACh. 11 - Prob. 29RACh. 11 - Prob. 30RACh. 11 - Prob. 31RACh. 11 - Prob. 32RACh. 11 - Prob. 33RACh. 11 - Distinguish between the genomic and nongenomic...Ch. 11 - Prob. 35RACh. 11 - Diabetics who require insulin injections can...Ch. 11 - Prob. 37RACh. 11 - Prob. 38RACh. 11 - Prob. 39RACh. 11 - Prob. 40RA
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- Discuss the roles of phospholipase A2, cyclooxygenase, and lipooxygenase.arrow_forward. Suggest the effects of each of the following mutations on the physio- logical role of chymotrypsinogen: (a) R15S (b) Cis (c) T147Sarrow_forwardIn 2-page worth of words (around 500), discuss CYCLAMATE's regulation, allowable levels, and what group of people are at high risk for the side effects of CYCLAMATE in the body.arrow_forward
- What is the physiological significance of the isozymic forms of lactate dehydrogenase (LDH)? Explain briefly.arrow_forwardThe PDH complex is a logical point of regulation in metabolism, as it links two major catabolic processes. Answer the following regarding the complex: a) Explain the advantage of E1, E2 and E3 working as a complex as opposed to separately. b) Explain the purpose of each of the three enzymes and their associated cofactors. c) NADH can inhibit the PDH complex directly or indirectly. What is the purpose of inhibition by NADH? d) Explain the differences between direct and indirect inhibition by NADH. Be sure to indicate the components involved and the mechanism of inhibition (impact on target component).arrow_forwardDescribe the two models that explain the binding of allosteric enzymes. Use either model to explain the binding ofoxygen to hemoglobin.arrow_forward
- Explain the function of histidine 57 in the mechanism of chymotrypsin.arrow_forwardExplain why, glucose-6-phosphate will prefer to go via the pentose phosphate route. What additional chemical is created by this route, and what role does it play in anabolic pathways?arrow_forwardIn own words, give 5 or more reasons why most of the clinical features of the diseases a-ketoglutarate dehydrogenase deficiency, succinate dehydrogenase deficiency, and fumarase deficiency involve muscle and nerve tissue? and explain those reasons. Cite used references.arrow_forward
- In Cyclooxygenase (COX) Inhibitors, how is prostaglandin synthesis; what are the mechanism of action for COX inhibitors; and compare and contrast COX-1 versus COX-2 selective inhibitors.arrow_forwardIn own words, give 5 or more reasons why most of the clinical features of the diseases a-ketoglutarate dehydrogenase deficiency, succinate dehydrogenase deficiency, and fumarase deficiency involve muscle and nerve tissue? and explain those reasons.arrow_forwardIn acute lymphoblastic leukemia, the cancerous white blood cells typically lack the enzyme asparagine synthetase. Why is the administration of asparaginase an eff ective therapy for this type of cancer?arrow_forward
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