HUMAN PHYSIO W/ APR & PHILS (LL) PKG
15th Edition
ISBN: 9781265382353
Author: Fox
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 11, Problem 20RA
Describe the sequence of events by which a hormone can cause an increase in the
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Trace in a stepwise manner the signaling pathway that involves a g-protein receptor leading to the release of intracellular calcium. Specify what class of hormones would be involved in this pathway.
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In the 1950s, Earl W. Sutherland, Jr., and his colleagues carried out pioneering experiments to elucidate the mechanism of action ofepinephrine and glucagon. Given what you have learned in this chapter about hormone action, interpret each of the experiments described below. Identify substance X and indicate the significance of the results.(a) Addition of epinephrine to a homogenate of normal liver resulted in an increase in the activity of glycogen phosphorylase. However, when the homogenate was first centrifuged at a high speed and epinephrine or glucagon was added to the clear supernatant fraction that contains phosphorylase, no increase in the phosphorylase activity occurred.(b) When the particulate fraction from the centrifugation in (a) was treated with epinephrine, substance X was produced. The substance was isolated and purified. Unlike epinephrine, substance X activated glycogen phosphorylase when added to the clear supernatant fraction of the centrifuged homogenate.(c)…
Chapter 11 Solutions
HUMAN PHYSIO W/ APR & PHILS (LL) PKG
Ch. 11 - Compare the four chemical classes of hormones with...Ch. 11 - Define prohormone and prehormone, and give...Ch. 11 - Prob. 1cCPCh. 11 - Prob. 2aCPCh. 11 - Prob. 2bCPCh. 11 - Prob. 3CPCh. 11 - Prob. 4aCPCh. 11 - Describe the sequence of events by which a hormone...Ch. 11 - Prob. 4cCPCh. 11 - Prob. 5aCP
Ch. 11 - Prob. 5bCPCh. 11 - List the hormones secreted by the anterior...Ch. 11 - Prob. 7CPCh. 11 - Prob. 8aCPCh. 11 - Prob. 8bCPCh. 11 - Prob. 9aCPCh. 11 - Prob. 9bCPCh. 11 - Describe the structure of the thyroid gland and...Ch. 11 - Describe how thyroid hormones are produced and how...Ch. 11 - Prob. 10cCPCh. 11 - Describe the location of the parathyroid glands...Ch. 11 - Prob. 12aCPCh. 11 - Describe how insulin and glucagon secretion are...Ch. 11 - Prob. 13CPCh. 11 - Prob. 14CPCh. 11 - Explain the nature of autocrine regulation. How...Ch. 11 - List some of the paracrine regulators produced by...Ch. 11 - Prob. 16aCPCh. 11 - Prob. 16bCPCh. 11 - Prob. 1RACh. 11 - Prob. 2RACh. 11 - Which of these statements about the adrenal cortex...Ch. 11 - Which of these statements about the hormone...Ch. 11 - Prob. 5RACh. 11 - Prob. 6RACh. 11 - Prob. 7RACh. 11 - Prob. 8RACh. 11 - Steroid hormones arc secreted by...Ch. 11 - Prob. 10RACh. 11 - Prob. 11RACh. 11 - Prob. 12RACh. 11 - Prob. 13RACh. 11 - Which of these hormones may have a primary role in...Ch. 11 - Prob. 15RACh. 11 - What do insulin-like growth factors,...Ch. 11 - Prob. 17RACh. 11 - Prob. 18RACh. 11 - Prob. 19RACh. 11 - Describe the sequence of events by which a hormone...Ch. 11 - Prob. 21RACh. 11 - Prob. 22RACh. 11 - Prob. 23RACh. 11 - Prob. 24RACh. 11 - Describe how thyroid hormone secretion is...Ch. 11 - Prob. 26RACh. 11 - Prob. 27RACh. 11 - Prob. 28RACh. 11 - Prob. 29RACh. 11 - Prob. 30RACh. 11 - Prob. 31RACh. 11 - Prob. 32RACh. 11 - Prob. 33RACh. 11 - Distinguish between the genomic and nongenomic...Ch. 11 - Prob. 35RACh. 11 - Diabetics who require insulin injections can...Ch. 11 - Prob. 37RACh. 11 - Prob. 38RACh. 11 - Prob. 39RACh. 11 - Prob. 40RA
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- Give two examples of feedback control of hormone activity.arrow_forwardWhat is the mechanism of action of a hormone that cyclic AMP as a second messenger?arrow_forwardA physician sees a patient whose symptoms include sluggishness, depression, and intolerance to cold. After eliminating other possible causes, the doctor diagnoses a hormone problem. What disorder fits the symptoms? Why does the doctor suspect that the underlying cause is a malfunction of the anterior pituitary gland?arrow_forward
- Explain why polar hormones cannot regulate their target cells without using second messengers. Alsoexplain in a step-by-step manner how cyclic AMP is used as a second messenger in hormone action.arrow_forwardHow are thyroid hormones transportes in the bloodstream ? Why ? Do the hormones enter the target cell directly ? Describe briefly the sequence of events when thyroid hormones bind to their receptors.arrow_forwardDescribe the most important actions of neurohypophyseal hormones. What are the effects of under secretion and oversecretion? Give some of the most common examples.arrow_forward
- In some cases, endocrine function can decline in old age even if there is little change in the level of hormone secretion.Explain why, and support your explanation with examples.arrow_forwardMechanisms by which hormones regulate cellular processes: Name a hormone and specify where it is produced. Name one of this hormone’s target tissues and explain where in a target cell you would expect to find the receptors for this hormone. Describe how the presence of the hormone alters the function of its target tissue.arrow_forwardDistinguish between the genomic and nongenomic actions of steroid hormones. Which mechanism of action would be inhibited by a drug that interfered with protein synthesis? Explain.arrow_forward
- A person with symptoms of hypothyroidism (i.e., sluggishness and intolerance to cold) is found to have abnormally low plasma concentrations of T4, T3, and TSH. After an injection of TRH, the plasma concentrations of all three hormones increase. Where is the site of the defect leading to hypothyroidism?arrow_forwardUnlike the glucocorticoid receptor, the thyroid receptor has an activity even in the absence of thyroid hormone. Explain the activity of the receptor under these conditions and how hormone binding changes the activity.arrow_forwardTake thyroid hormones as an example of hormones and their properties. Thyroid hormone is highly bound to proteins in the blood. What is the benefit of such protein binding? What effect does protein binding have on the activity of the hormone? Name a gland other than the thyroid gland that is involved in regulating thyroid hormone production?arrow_forward
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