Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 10, Problem 3P
Compare and contrast the contributions of Neel, Pauling, and Ingram to our understanding of the genetic and molecular bases of sickle cell disease.
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Mad cow disease, or bovine spongiform encephalopathy, appears to be caused by a novel infectious agent: a protein that replicates by causing related proteins to modify their structure from a harmless shape to a dangerous one. These prions (short for “proteinaceous infectious particles”) also appear to be the cause of several other spongiform encephalopathy diseases, such as scrapie in sheep, and kuru and Creutzfeldt-Jakob disease in humans. Which of the following observations or experiments would not support the hypothesis that a prion causes spongiform encephalopathy? (a) The brains of many sheep with scrapie contain prion proteins, but the brains of most sheep without scrapie do not. (b) There is a high incidence of kuru in populations of people who consume brain tissue from prion-infected animals. (c) Coyotes that feed on cows with mad cow disease do not subsequently develop spongiform encephalopathy. (d) When introduced into sheep brain cells in culture, prions cause the normal…
Chapter 10 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 10 - Define the following terms as described in this...Ch. 10 - 2. Using sickle cell disease as an example,...Ch. 10 -
3. Compare and contrast the contributions of...Ch. 10 - Why do differences in protein electrophoretic...Ch. 10 - Prob. 5PCh. 10 - Prob. 6PCh. 10 - Prob. 7PCh. 10 - 8. Wildtype βglobin protein is composed of amino...Ch. 10 - Prob. 9PCh. 10 - Prob. 10P
Ch. 10 - 11. How is an autoradiograph produced from a...Ch. 10 - Prob. 12PCh. 10 - Prob. 13PCh. 10 - Prob. 14PCh. 10 - The family represented in the pedigree and...Ch. 10 - Suppose the mating couple (I-1 and I-2) shown in...Ch. 10 - What are restriction endonucleases, and why are...Ch. 10 - 18. Following restriction digestion, DNA fragments...Ch. 10 - 19. The doublestranded DNA sequence below is part...Ch. 10 - 20. Restriction enzymes recognize specific...Ch. 10 - Prob. 21PCh. 10 - Prob. 22PCh. 10 - Prob. 23PCh. 10 - Prob. 24PCh. 10 - 25. A second strain of dwarf plants has a...Ch. 10 - During gel electrophoresis of linear DNA...Ch. 10 - Prob. 27PCh. 10 - 28. In molecular biology, restriction...Ch. 10 - A complete plant gene containing four introns and...Ch. 10 - Prob. 30PCh. 10 - The map below illustrates three alleles in a...Ch. 10 - Prob. 32PCh. 10 - 33. Northern blot analysis is performed on mRNA...
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- Consider the expression “central dogma,” which refers to the flow of genetic information from DNA to RNA to protein. is the word “dogma” appropriate in this context?arrow_forwardwhich of the following statements about genome-wide association studies (GWAS) is correct? A) involves scanning the genomes of thousands of unrelated individuals with a particular mutation and comparing them with the genomes of individuals who do not have the mutation. B) involves scanning the genomes of thousands of unrelated individuals with a particular disease and comparing them with the genomes of individuals who do not have the disease C) attempt to identify genes that influence mutation risk D) attempt to identify genes that influence disease risk E) involves scanning the genomes of thousands of unrelated individuals with a particular disease and comparing them with the genomes of individuals who do not have the disease and GWAS attempt to identify genes that influence disease riskarrow_forwardCan you help me to explain to me because i struggled with my homework?arrow_forward
- Chemical mutagens often cause oxidation or deamination of DNA bases. This can lead to cancer by causing: A) Activation of replication. B) Activation of transcription. C) Non Watson-Crick base pairing. OD) Changes to cytochrome P450 enzymes. OE) Activation of translation.arrow_forwardWhy didn't Rosalind Franklin get her due recognition for her work with DNA? A)All of the options are correct. B)Because it appeared she was only confirming the work of Watson and Crick. C)Because she died shortly after her discovery. D)The Because her publication was placed after Watson and Crick's.arrow_forwardThe amino acid sequences of thousands of different proteins from many species have been determined using principles first developed by? a) Watson and Crick b) Edman c) Sanger d) Mendelarrow_forward
- a) What is gene mutation? and what are the causes and consequences of gene mutation? b)With illustrations, write concisely on gene mutation with emphasis on (i) Point Mutation (ii) Silent Mutation (iii) Frameshift Mutationarrow_forwardXeroderma pigmentosum is a genetic disease caused by an error in the nucleotide excision repair process that fixes damage to DNA by ultraviolet light. Studies have shown that it can result from mutations in any one of seven genes. What can you infer from this finding? A) There are seven genes that produce the same protein B) These seven genes are the most easily damaged by ultraviolet light. C) There are seven enzymes involved in the nucleotide excision repair process. D) These mutations have resulted from translocation of gene segments.arrow_forward(b) Correct and rewrite the statement by changing the biological term that is underlined for each statement: (i) The theory of Inher.ance of Acquired Characters was proposed by Watson and Crick. (ii The protective sac which develops around the developing embryo is called the Pericardium, (iii) Maintaining balance of the body and coordinating muscular activities is carried by the cerebrum. (iv) The kidney is composed of number of neurons. (v) The part of the eye which can be donated from a clinically dead person is the Retina.arrow_forward
- A mutation is most often cause by which of the following factors? a) Sunlight b) Smoking c) Random Copy error d) Radiationarrow_forwardA neutral mutation is, by definition, a mutation that does not result in the change of the encoded amino acid sequence of a gene. 1)True 2)Falsearrow_forwardAn example sequence corresponds to human sickle cell beta-globin mRNA and that this disease results from a point mutation in the β globin gene. In the following section, you will compare sickle cell and normal β globin sequences to reveal the nature of the sickle cell mutation at the protein level. To do this you need to find at least one sequence representing the normal beta globin gene. Open a new window and visit the NCBI home page(http://www.ncbi.nlm.nih.gov) and select “Nucleotide” from the drop menu associated with the top search box. Then enter the search term: HBB . Note that lots of irrelevant results are returned so let's apply some “Filters” (available by clicking in the left-hand sidebar) to focus on RefSeq entries for Homo sapiens. Remember that we are after mRNA so we can compare to the mRNA sequence from part 1 above. QUESTION #1: What is the ACCESSION number of the “Homo sapiens hemoglobin, beta (HBB), mRNA” entry? NOTE: Boolean operators (NOT, AND, OR) as…arrow_forward
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