Chemical mutagens often cause oxidation or deamination of DNA bases. This can lead to cancer by causing: A) Activation of replication. B) Activation of transcription. OC) Non Watson-Crick base pairing. OD) Changes to cytochrome P450 enzymes. E) Activation of translation.
Chemical mutagens often cause oxidation or deamination of DNA bases. This can lead to cancer by causing: A) Activation of replication. B) Activation of transcription. OC) Non Watson-Crick base pairing. OD) Changes to cytochrome P450 enzymes. E) Activation of translation.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Introduction
DNA damage is often caused by external sources like radiation exposure, exogenous chemical reactions and also from endogenous damages. Such damages lead to formation of carcinogens and lead to cancer in the body.
The oxidation and deamination of bases can lead to a change in the nucleotide sequence in DNA. For example, oxidative deamination of Cytosine changes it to Uracil. This would lead to GC base pairs getting substituted by AU base pairs.
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