Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 10, Problem 9P
Summary Introduction
To analyze:
Justify the statement,“Sickle cell disease is arecessive genetic disorder.”
Introduction:
Sickle cell disease is an inheritable molecular disease related with the red blood cells, caused by the presence of abnormal hemoglobin molecules as a result of mutation in the hemoglobin gene. In autosomal recessive condition, inheritance of two mutated genes is required, one from each parent. An autosomal disorder can be occurred due to the mutation in a gene on one of the first
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Suppose a woman who is a carrier of sickle-cell trait (making her a heterozygote) has children with a man who is totally healthy and does not carry the gene for sickle-cell trait at all. Which one of the following is true about their potential children? (Draw a Punnett square on scratch paper if it helps you.)
A) None of their children will have sickle-cell disease.
B) All of their children will have sickle-cell disease.
C) All of the couple's children would be heterozygous carriers like the mother.
What category of genetic disorders does albinism disorder fit into ( single gene defect, multifactorial defect, mitochondrial disorder or chromosome abnormalities)? Explain
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Chapter 10 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 10 - Define the following terms as described in this...Ch. 10 - 2. Using sickle cell disease as an example,...Ch. 10 -
3. Compare and contrast the contributions of...Ch. 10 - Why do differences in protein electrophoretic...Ch. 10 - Prob. 5PCh. 10 - Prob. 6PCh. 10 - Prob. 7PCh. 10 - 8. Wildtype βglobin protein is composed of amino...Ch. 10 - Prob. 9PCh. 10 - Prob. 10P
Ch. 10 - 11. How is an autoradiograph produced from a...Ch. 10 - Prob. 12PCh. 10 - Prob. 13PCh. 10 - Prob. 14PCh. 10 - The family represented in the pedigree and...Ch. 10 - Suppose the mating couple (I-1 and I-2) shown in...Ch. 10 - What are restriction endonucleases, and why are...Ch. 10 - 18. Following restriction digestion, DNA fragments...Ch. 10 - 19. The doublestranded DNA sequence below is part...Ch. 10 - 20. Restriction enzymes recognize specific...Ch. 10 - Prob. 21PCh. 10 - Prob. 22PCh. 10 - Prob. 23PCh. 10 - Prob. 24PCh. 10 - 25. A second strain of dwarf plants has a...Ch. 10 - During gel electrophoresis of linear DNA...Ch. 10 - Prob. 27PCh. 10 - 28. In molecular biology, restriction...Ch. 10 - A complete plant gene containing four introns and...Ch. 10 - Prob. 30PCh. 10 - The map below illustrates three alleles in a...Ch. 10 - Prob. 32PCh. 10 - 33. Northern blot analysis is performed on mRNA...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- What is the genetic basis and phenotype for each of the following disorders (use proper genetic notation)? a. Edwards syndrome b. Patau syndrome c. Klinefelter syndrome d. Down syndromearrow_forwardSickle-cell disease is an autosomal recessive genetic disorder. How many mutated hemoglobin alleles do people with sickle-cell disease have?arrow_forwardIs the sickle cell allele dominant or recessive? Explain. What is sickle cell trait?arrow_forward
- Genetic disorders Complete the following statements to describe several genetic disorders and their symptoms. Choices can be used more than once. The disorder called causes blue-colored skin, sickle-cell disease osteogenesis imperfecta The disorder called that leads to weakened, brittle bones. causes defective collagen methemoglobinemia autosomal dominant The disorder called causes abnormally thick mucus in the bronchial tubes and pancreatic ducts. autosomal recessive The disorder called leads to progressive cystic fibrosis degeneration of neurons in the brain. alkaptonuria The disorder called causes urine to be black. Huntington disease acer %23 24 & 4 8. 9. e y u < 6arrow_forwardIs Miller Fisher syndrome hereditary?arrow_forwardTuberous Sclerosis (TS) is an autosomal dominant genetic disease characterized by seizures, mental retardation, autism, and benign tumors of the brain, heart, skin, and kidneys. The kidney tumors can also be malignant. This disease exhibits a wide range of severity, and only about 1/3 of the cases are inherited. Two different genes have been tightly linked to the disease in families where it is inherited. The remaining 2/3 appear to be due to mutations in one of the 2 genes as well. Overall it appears that 1/2 are caused by mutations in TSC1 and the other half by mutations in TSC2. A rat model for hereditary renal carcinoma (kidney cancer) has been found. Southern and Northern blot analysis of the TSC1 and TSC2 gene revealed no differences between these rats and normal rats. Not all the rats in the strain would get cancer but a significant proportion did and those were selected for and used in experiments. 1. a) What was detected by the Southern blots? (look this up, make your…arrow_forward
- Explain how various genetic disorders can occur.arrow_forwardAchondroplasia is an autosomal dominant disorder characterized by disproportionate short stature: the legs and arms of people with achondroplasia are short compared with the head and trunk. The disorder is due to a base substitution in the gene, located on the short arm of chromosome 4, that encodes fibroblast growth factor receptor 3 (FGFR3). Although achondroplasia is clearly inherited as an autosomal dominant trait, more than 80% of the people who have achondroplasia are born to parents with normal stature. This high percentage indicates that most cases are caused by newly arising mutations; these cases (not inherited from an affected parent) are referred to as sporadic. Studies have demonstrated that sporadic cases of achondroplasia are almost always caused by mutations inherited from the father (paternal mutations). In addition, the occurrence of achondroplasia is higher among the children of older fathers; approximately 50% of children with achondroplasia are born to fathers…arrow_forwarda man has simpson syndrome, an addiction to certain television series. his wife does not have this syndrome. the couple has four children. A) can this syndrome be caused by autosomal recessive gene? B) Can it be caused by an x linked recessive allele ? C) What about wiggly ears?arrow_forward
- PKU is an inherited disease caused by a recessive allele. If a woman and her husband, who are both carriers (heterozygotes) for the disorder, have three children, what is the probability of each of the following? a) All three children are of normal phenotype. b) All three children have the disease. c) Any 2 of the three children have the normal phenotype.arrow_forwardWhich of the following genetic diseases is/are inherited as an autosomal dominant trait: sickle cell anemia, hemophilia A, Huntington’s disease?arrow_forwardWhy Recessive CF disease alleles either produce no CFTR or produce nonfunctional or less functional versions of the protein?arrow_forward
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