Syt1 point mutation is a point mutation in synaptotagmin-1.A. How did the experiment shown in the figure below show that synaptotagmin wasprobablythe Ca²+ sensor?normalized amplitudeof synaptic response1.51.00.5-Syt1 point mutation- wild typeCa²+ (mm)10

Answered: Syt1 point mutation is a point mutation…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Syt1 point mutation is a point mutation in synaptotagmin-1.
A. How did the experiment shown in the figure below show that synaptotagmin was
probably
the Ca²+ sensor?
normalized amplitude
of synaptic response
1.5
1.0
0.5
-Syt1 point mutation
- wild type
Ca²+ (mm)
10

Expert Solution

Step 1

Synaptotagmin-1, a protein that detects calcium ions at synapses, collaborates with the SNARE complex, a collection of proteins, to aid in the fusion of vesicles with cell membranes. Three distinct structures of synaptotagmin-1 coupled to the SNARE complex have been described in earlier research. Which of these binding states, though, truly causes the release of neurotransmitters was unclear.

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