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Referring to the signalling diagrams, complete the table below. Consider how cell signalling will proceed in a cell exposed to hormone H with each of the following homozygous mutations.

Referring to the signalling diagrams, complete the table below. Consider how cell signalling will proceed in a cell exposed to hormone H with each of the following homozygous mutations.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Practice question 1C) Referring to the signalling diagrams, complete the table below. Consider how cell signalling will proceed in a cell exposed to hormone H with each of the following homozygous mutations. НК expressed? | Суclin A cell cycle expressed? progression? cell survival compared with wild type. Mutant (# refers to the active ? mutants listed above) (same, more, less) (yes/no) (yes/no) (yes/no) (yes/no) # 4 # 5 #1 + #2 Below is a list of mutations commonly found in different components of the hormone-signaling pathways. Mutant #1: The içRuundergoes a loss-of-function mutation. Mutant #2: GSK-3B can no longer be phosphorylated. Mutant #3: ERK is constitutively active. Mutant #4: Lyn undergoes a gain-of function mutation. Mutant #5: The cyclin A gene's DNA is highly compacted and inaccessible. Mutations in the signalling pathways depicted above have been associated with an increased incidence of several types of cancer. hormone H H extracellular fluid inactive GTP inactive RAS cell-surface Lyn icR. H receptor for H (csR.) GDP RAS-GTP hexose metabolism cell survival ↑ icRu G, phase (resting) Raf HK GSK-3B MEK M hexose kinase ERK promoter HRE CDK1 Cyclin A nucleus cyclin A Fos V promoter a Created in BioRender.com bio
Transcribed Image Text:Practice question 1C) Referring to the signalling diagrams, complete the table below. Consider how cell signalling will proceed in a cell exposed to hormone H with each of the following homozygous mutations. НК expressed? | Суclin A cell cycle expressed? progression? cell survival compared with wild type. Mutant (# refers to the active ? mutants listed above) (same, more, less) (yes/no) (yes/no) (yes/no) (yes/no) # 4 # 5 #1 + #2 Below is a list of mutations commonly found in different components of the hormone-signaling pathways. Mutant #1: The içRuundergoes a loss-of-function mutation. Mutant #2: GSK-3B can no longer be phosphorylated. Mutant #3: ERK is constitutively active. Mutant #4: Lyn undergoes a gain-of function mutation. Mutant #5: The cyclin A gene's DNA is highly compacted and inaccessible. Mutations in the signalling pathways depicted above have been associated with an increased incidence of several types of cancer. hormone H H extracellular fluid inactive GTP inactive RAS cell-surface Lyn icR. H receptor for H (csR.) GDP RAS-GTP hexose metabolism cell survival ↑ icRu G, phase (resting) Raf HK GSK-3B MEK M hexose kinase ERK promoter HRE CDK1 Cyclin A nucleus cyclin A Fos V promoter a Created in BioRender.com bio
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