JakJak1. Receptors bindcytokines, dimerize,and bind JaksPP2. Jaks phosphorylateeach other and thereceptor25STATCytosol4.STATS dissociate fromreceptor, dimerize,translocate to nucleus3. Receptor binds andphosphorylates STATSWhat is the ligand?What happens when the phosphorylated STAT proteins dimerize?What are the products of this pathway?Which protein in this signaling cascade is a transcription factor?What does a transcription factor do? 1. Which Ga proteinactivates adenylyl cyclase?2. Which form of the Gaprotein is active (GTPbound or GDP)?3. What is the purpose of thebeta and gamma Gproteins?4. Ga is also a GTPase. Whatdoes a GTPase do?Convert GTP to GDP? OrConvert GDP +Pi to GTP?adenylyl cyclaseAdenylate cyclaseGTPH₂O P₁Figure 13.08Biochemistry, Third Edition2015 W.H. Freeman and CompanyGDPoooobetagammaOOOGDPalpha

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Answered: Jak Jak 1. Receptors bind cytokines,…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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The activity provides you with a version of the NGF pathway, an example of a RTK. All of the proteins involved can be in ON/OFF states. Using this cell signaling pathway you will be asked a variety of questions to determine how the molecules are regulated, but also how a cell would respond if this cell signaling party steps were interrupted or activated. Neural Growth Factir (NGF) Ras- Ras- GDP GTP Trk-A Ras-GEF braf braf МЕК МЕК ERK ERK ERK ERK STAT STAT Spiouty DNA Nucleus Cytosol
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Which of the following small GTP-binding proteins does NOT play a role in cell migration during chemotaxis? O Cap Z Rho Cdc42 O All of the listed GTPases play a role in cell migration O Rac ◆ Previous
In Xenopus, one of the substrates of mitotic CDKs is the phosphatase Cdc25. When phosphorylated by mitotic CDKs, Cdc25 is activated. What is the substrate of Cdc25? How does this information help to explain the rapid rise in mitotic CDK activity as cells enter mitosis?
Opiods cause ligand-gated K+ channels to open and move with their concentration gradient from high to low (into or out) Blank 1. Fill in the blank. of the cell, causing the membrane potential to (hyperpolarize or depolarize) Blank 2. Fill in the blank. Fill in the blank using one of the options in the parenthesis
N-term N- ER Signal Sequence Part of BHCC Protein N-terminus Middle of Protein C-terminus 19a. Which parts of the BHCC protein would be: Body Text 2* 2 BHCC PROTEIN SEQUENCE # ER Stop Transfer 3 A) inside the Rough ER organelle (in the ER lumen) B) inside the Rough ER membrane (transmembrane) C) in the cytosol $ Where it is located after translation (A, B, or C) ANSWER ANSWER ANSWER 4 Middle A B % 5 ER Start Transfer I MacBook Pro 6 "1"' & 7 FLEEEEE C-term C
Which is most important in catalysis of peptidyl transfer? A Massively parallel sequencing data collection based on nanofluidics and nanoimaging b Release of histamine by mast cells in response to wound c Assist by 2+-OH on A76 ribose of p- site RNA d Complement system of 20-30 proteins in coordinated innate immune response e Nucleophilic attack on incoming dntp by 3-OH on deoxyribose at 3 ' end of primer

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