ay, an example of a RTK. All of the proteins involved can be in ON/OFF states. Using this cell signaling pathway you will be asked a variety of questions to determine how the molecules are regulated, but also how a cell would respond if this cell signaling party steps vere interrupted or activated. Neural Growth Factir (NGF) Ras- Ras- GDP GTP Trk-A Ras-GEF braf braf МЕК МЕК ERK ERK ERK ERK STAT STAT Spiouty DNA Nucleus Cytosol

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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The activity provides you with a version of the NGF pathway, an example of a RTK. All of the proteins
involved can be in ON/OFF states. Using this cell signaling pathway you will be asked a variety of questions to
determine how the molecules are regulated, but also how a cell would respond if this cell signaling party steps
were interrupted or activated.
Neural Growth
Factir (NGF)
Ras-
Ras-
GDP
GTP
Trk-A
Ras-GEF
braf
braf
МЕК
МЕК
ERK
ERK
ERK
ERK
STAT
STAT
Spiouty DNA
Nucleus
Cytosol
Transcribed Image Text:The activity provides you with a version of the NGF pathway, an example of a RTK. All of the proteins involved can be in ON/OFF states. Using this cell signaling pathway you will be asked a variety of questions to determine how the molecules are regulated, but also how a cell would respond if this cell signaling party steps were interrupted or activated. Neural Growth Factir (NGF) Ras- Ras- GDP GTP Trk-A Ras-GEF braf braf МЕК МЕК ERK ERK ERK ERK STAT STAT Spiouty DNA Nucleus Cytosol
3. For the remaining questions each question is a different scenario. Use the signaling pathway to EXPLAIN why the
cell will respond in a particular way. Keep in mind the purpose of this signaling pathway is to induce a cell to extend
axons by turning on sprout transcription.
A) You have added a non-hvdrolvzable version of GTP (it cannot become GDP) to a cell that is normally destined to
become a neuron and added NGF to the cell media (liquid food for the cell).
B) You discovered a mutation in a cell that was destined to be a neuron in which phosphorylated-ERK is unable to bind
phosphorylated STAT and you added NGF to the cell media.
Transcribed Image Text:3. For the remaining questions each question is a different scenario. Use the signaling pathway to EXPLAIN why the cell will respond in a particular way. Keep in mind the purpose of this signaling pathway is to induce a cell to extend axons by turning on sprout transcription. A) You have added a non-hvdrolvzable version of GTP (it cannot become GDP) to a cell that is normally destined to become a neuron and added NGF to the cell media (liquid food for the cell). B) You discovered a mutation in a cell that was destined to be a neuron in which phosphorylated-ERK is unable to bind phosphorylated STAT and you added NGF to the cell media.
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