The amino acid at the β82 position is in the central cavity that binds 2,3-bisphosphoglycerate in the deoxygenated form of hemoglobin. How would the mutation of Lys to Asn affect the ability to bind to 2,3-BPG?   a. It would have no effect.   b. It would have decreased 2,3-BPG binding.   c. It would have increased 2,3-BPG binding.   d. It would have increased 2,3-BPG binding at least two fold.

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter10: From Proteins To Phenotypes
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Problem 20QP: If an extra nucleotide is inserted in the first exon of the beta globin gene, what effect will it...
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The amino acid at the β82 position is in the central cavity that binds 2,3-bisphosphoglycerate in the deoxygenated form of hemoglobin. How would the mutation of Lys to Asn affect the ability to bind to 2,3-BPG?
 
a. It would have no effect.
 
b. It would have decreased 2,3-BPG binding.
 
c. It would have increased 2,3-BPG binding.
 
d. It would have increased 2,3-BPG binding at least two fold.
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