a change that decreases the rate of hydrolysis of GTP by Ras a change that increases the affinity of Ras for GDP a change that decreases the affinity of Ras for GTP O a change that prevents Ras from being made
Q: Cancers are often caused by overactive growth factor receptor signaling (remember growth factor…
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Q: When Ras is activated, cells will divide. A dominant-negative form of Ras clings too tightly to GDP.…
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Q: Predict the eff ect on cell growth of an Sos mutation that decreased its affi nity for Ras.
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A: a) Mature ras protein are located on the inner side of the plasma membrane, and their biochemical…
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A: Introduction Lethality means the ability to kill. MYC stands for Master Regulator of Cell Cycle…
Q: Ras proteins are activated when they a. bind GTP. b. release GTP. c. bind GDP. d. undergo…
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Q: The use of an SH2 domain binding inhibitor would be predicted to: O Decrease binding of SOS with RAS…
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Q: Which of the following are characteristics of “small” monomeric Ras GTPases? A. Membrane…
A: Answer : The correct option is C because, RAS protein RAS proteins are small group of GTPase which…
Q: Suppose that Protein J which is a hypothetical protein kinase receptor was determined to be related…
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Q: CTP synthetase is allosterically activated by GTP. What function might this play in the cell?
A: CTP synthetase is an enzyme which converts UTP ( Uridine Triphosphate) to CTP ( Cytidine…
Q: GTP binding proteins, which act as molecular switches inside cells activate by the GTPase action on…
A:
Q: The egfr kinase independent transactivation of the ras pathway does require egfr. Explain this…
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Q: A mutation in the Ras protein renders Ras constitutively active (RasD). What is constitutive…
A: The Ras protein can be referred to as tiny G protein that requires phosphorylation of guanosine…
Q: Ras activation can activate O MAP kinase O Protein kinase B Phospholipase C O Two of the above O All…
A: Ras, a tiny GTP-binding protein, is a key component of the signal transduction pathway that growth…
Q: In the normal cycle of Ras activity, when Ras is bound to it is inactive. Activation of Ras involves…
A: Ans- In the normal cycle of RAS activity, when RAS bound to GDP it is inactive. Activation of RAS…
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A: Signal transduction also known as cell signaling is a process in which signals in the form of…
Q: Some elongation factors are evolutionarily related to the G-proteins involved in signal…
A: The elongation factors and the G proteins are evolutionary related. both of them utilise the high…
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Q: Which molecule(s) is directly activated by Ras-GTP? A. Gene regulatory proteins B. ERK (MAP kinase)…
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A:
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Q: How would a mutation that prevents the Ras proteinfrom hydrolyzing GTP affect the cell-signaling…
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Q: Cyclic-AMP stimulates which of the following? a) PKA b) PKC c) Ras d) RTK
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Q: The G-protein Ras is involved in proliferative signaling, and is mutated is a large fraction of…
A: Ras is the family of small GTPase proteins that are involved in cellular signal transduction. Ras…
Q: Suppose that Protein J which is a hypothetical protein kinase receptor was determined to be related…
A: The dissociation constant is the equilibrium constant for the dissociation of a Protein-Ligand…
Q: CAMP (cyclic adenosine monophosphate) is a molecule that can activate kinase enzymes allosterically…
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a change that increases the affinity of Ras for GDP
a change that decreases the affinity of Ras for GTP
O a change that prevents Ras from being made](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F57a49ddc-b088-4a97-a76b-d7a72471553b%2Ffe402d67-1e28-433c-8274-852d2f563fad%2F1t254e.jpeg&w=3840&q=75)
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- The egfr kinase independent transactivation of the ras pathway does require egfr. Explain this apparent contradiction.The ras protein is a mutated G protein that lacks GTPase activity. How does the absence of this activity affect the adenylyl cyclase pathway?Explain why in cells that are genetically NF1–/–, basal levels of GTP-bound activated Ras are higher than normal and respond to growth factor stimulation by increasing rapidly to far higher levels.
- Compare and contrast the regulation of Ras with trimeric G proteins.Some elongation factors are evolutionarily related to the G-proteins involved in signal transduction. Provide a possible reason why this is the case.The use of an SH2 domain binding inhibitor would be predicted to: O Decrease binding of SOS with RAS O Decrease binding between EGFR and GRB2 O Decrease PI3K binding with PIP2 O Decrease GRB2 binding with SOS
- RGS proteins accelerate the GAP activity of Gα subunits. What is the direct result of this GAP activity? - hydrolysis of GTP, resulting in a GDP-bound Gα - phosphorylation of GDP to GTP, resulting in a GTP-bound Gα - an exchange of GTP for GDP bound to Gα - an exchange of GDP for GTP bound to GαWhich of the following mutations would produce a form of the Ras protein that would be more difficult to inactivate than normal Ras? Briefly explain your reasoning.(i) A mutation that allows Ras to cleave (hydrolyze) GTP more rapidly than usual(ii) A mutation that causes Ras to bind Ras-GAP more tightly than usual(iii) A mutation that causes Ras to cleave (hydrolyze) GTP more slowly than usualList the three 'effector' signaling pathways activated by the Ras protein.
- In the normal cycle of Ras activity, when Ras is bound to y activity that removes a phosphate to convert GTP back to GDP and this it is inactive. Activation of Ras involves exchanging GDP for The Ras protein has intrinsic Ras. inactivates activates ATP GTP «< Questic A Moving to another question will save this response. ADP GDP GTPase Clo nucleaseSome strains of bacteria or microorganisms have developed toxins that can modify the activity of the alpha subunit of G proteins which results in disease. For ex. cholera toxin, produced by Vibrio cholerae, causes ADP ribosylation of the stimulatory Gαs subunit of G proteins. This modification abolishes the GTPase of Gαs, and results in an αs subunit that is always in the “on” or active state. It results in continuous stimulation of adenylyl cyclase (AC). The main cells affected by this are the epithelial cell in gastrointestinal tract. Knowing this altered activity of AC, explain why patients affected by this toxin experience severe diarrhea and dehydration that may result in death.From experiments in which cells expressing normal myosin II heavy chain were altered to either lack (mhckA-) or overexpress (MHCKA ++) a myosin heavy chain kinase (MHCKA). For answering this question recall the earlier the variants on the myosin II heavy chain, in which three key threonines, normally subject to reversible phosphorylation, were altered in various ways: 3X Ser = Serines in place of Threonines 3X Ala = Alanines in place of Threonines 3X Asp = Aspartate in place of Threonines MHCKA is present at normal levels. Which of the two mutants (mhcp- or MHCP++) would be most likely to have a defect in cytokinesis?
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