Sort the following events to reflect the order in which they should occur during vesicle docking ontoand fusing with a target membrane.1. Rab binds to its effector (tethering protein) on the target membrane.2. GTP in Rab is hydrolyzed to GDP3. Rab associates with the vesicle membrane in its GTP-bound form.4. Rab dissociates from the membrane.3241312432143412 Which of the following is the LEAST likely ER signal sequence? All sequences are written with theirN-terminus on the left.Met-Lys-Leu-Ser-Leu-Val-Ala-Ala-lle-Leu-Leu-Leu-Leu-Ser-Ala-Ala-Arg-AlaMet-Glu-Met-Phe-Gln-Gly-Leu-Leu-Leu-Leu-Leu-Leu-Leu-Leu-Ser-Met-Gly-Gly-Thr-Trp-AlaMet-Lys-Ala-Lys-Leu-Leu-Val-Leu-Leu-Tyr-Ala-Phe-Val-Ala-Gly-AsnMet-Leu-Ser-Lys-Arg-Gln-Ser-Lys-Arg-Arg-Lys-Lys-Pro-Ala-Thr-Arg-Thr-Lys-Ser-Ser-Arg-Tyr-Leu

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Description: Sort the following events to reflect the order in which they should occur during vesicle docking ontoand fusing with a target membrane.1. Rab binds to its effector (tethering protein) on the target membrane.2. GTP in Rab is hydrolyzed to GDP3. Rab a

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Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Sort the following events to reflect the order in which they should occur during vesicle docking onto
and fusing with a target membrane.
1. Rab binds to its effector (tethering protein) on the target membrane.
2. GTP in Rab is hydrolyzed to GDP
3. Rab associates with the vesicle membrane in its GTP-bound form.
4. Rab dissociates from the membrane.
3241
3124
3214
3412

Which of the following is the LEAST likely ER signal sequence? All sequences are written with their
N-terminus on the left.
Met-Lys-Leu-Ser-Leu-Val-Ala-Ala-lle-Leu-Leu-Leu-Leu-Ser-Ala-Ala-Arg-Ala
Met-Glu-Met-Phe-Gln-Gly-Leu-Leu-Leu-Leu-Leu-Leu-Leu-Leu-Ser-Met-Gly-Gly-Thr-Trp-Ala
Met-Lys-Ala-Lys-Leu-Leu-Val-Leu-Leu-Tyr-Ala-Phe-Val-Ala-Gly-Asn
Met-Leu-Ser-Lys-Arg-Gln-Ser-Lys-Arg-Arg-Lys-Lys-Pro-Ala-Thr-Arg-Thr-Lys-Ser-Ser-Arg-Tyr-Leu

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Question 1

Answer correct option (b) 3124

Vesicle have bounded Rab-GTP which interacts with Rab effector molecule present on membrane for correct positioning of vesicle, this process called membrane tethering. Later, Rab-GTP hydrolyzed to Rab-GDP at this point there is formation of trans SNARE complex, this process is called docking . Now Rab discossiates from membrane and vesicle fusion takes place.

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