Bovine insulin is composed of two polypeptide chains that are linked together covalently. The two chains have the following sequences: GIVEQCCASVCSLYQLENYCN - A chain FVNQHLCGSHLVEALYLVCGERGFFYTPKA - B chain a. Through which amino acids are these two chains linked together covalently? b. How many different ways can these two chains be linked? c. Of the different connectivities you enumerated in part b, which is the biologically active form?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Bovine insulin is composed of two polypeptide chains that are linked together covalently. The two chains have the following sequences:

- GIVEQCCASVCSLYQLENYCN – A chain
- FVNQHLCGSHLVEALYLVCGERGFFYTPKA – B chain

a. Through which amino acids are these two chains linked together covalently?

b. How many different ways can these two chains be linked?

c. Of the different connectivities you enumerated in part b, which is the biologically active form?
Transcribed Image Text:Bovine insulin is composed of two polypeptide chains that are linked together covalently. The two chains have the following sequences: - GIVEQCCASVCSLYQLENYCN – A chain - FVNQHLCGSHLVEALYLVCGERGFFYTPKA – B chain a. Through which amino acids are these two chains linked together covalently? b. How many different ways can these two chains be linked? c. Of the different connectivities you enumerated in part b, which is the biologically active form?
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