In the folded protein, His108 forms a salt bridge with Asp44. The pKa of the imidazole functional group in the side chain of histidine is 6.0. The pKa of the carboxylic acid functional group in the side chain of aspartate is 4.1. How do you think the pKa of the side chain of His108 will change in the folded protein? a. The pKa will be > 6.0. b. The pKa will be < 6.0. c. The pKa will not change. Use chemical reasoning to justify your answer
Enzyme kinetics
In biochemistry, enzymes are proteins that act as biological catalysts. Catalysis is the addition of a catalyst to a chemical reaction to speed up the pace of the reaction. Catalysis can be categorized as either homogeneous or heterogeneous, depending on whether the catalysts are distributed in the same phase as that of the reactants. Enzymes are an essential part of the cell because, without them, many organic processes would slow down and thus will affect the processes that are important for cell survival and sustenance.
Regulation of Enzymes
A substance that acts as a catalyst to regulate the reaction rate in the living organism's metabolic pathways without itself getting altered is an enzyme. Most of the biological reactions and metabolic pathways in the living systems are carried out by enzymes. They are specific for their works and work in particular conditions. It maintains the best possible rate of reaction in the most stable state. The enzymes have distinct properties as they can proceed with the reaction in any direction, their particular binding sites, pH specificity, temperature specificity required in very few amounts.
In the folded protein, His108 forms a salt bridge with Asp44. The pKa of the imidazole
group in the side chain of aspartate is 4.1. How do you think the pKa of the side chain of
His108 will change in the folded protein?
a. The pKa will be > 6.0.
b. The pKa will be < 6.0.
c. The pKa will not change.
Use chemical reasoning to justify your answer.
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