You have discovered a novel protein that has a pl = 5.5. To study the functional properties of this new protein your research group has made a mutant that contains two amino acid changes-namely, a surface Phe residue in the normal protein has been replace by His (side chain pk, = 6.1), and a surface Gln has been replace by Glu (side chain pk = 6.0). The pl of the %3D mutant protein is predicted to be: A. Greater than the pl of the normal protein.

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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You have discovered a novel protein that has a pl = 5.5. To study the functional properties of
this new protein your research group has made a mutant that contains two amino acid
changes-namely, a surface Phe residue in the normal protein has been replace by His (side
chain pk = 6.1), and a surface Gln has been replace by Glu (side chain pk. = 6.0). The pl of the
mutant protein is predicted to be:
A. Greater than the pl of the normal protein.
B. Less than the pl of the normal protein.
C. The same as the pl of the normal protein.
Transcribed Image Text:You have discovered a novel protein that has a pl = 5.5. To study the functional properties of this new protein your research group has made a mutant that contains two amino acid changes-namely, a surface Phe residue in the normal protein has been replace by His (side chain pk = 6.1), and a surface Gln has been replace by Glu (side chain pk. = 6.0). The pl of the mutant protein is predicted to be: A. Greater than the pl of the normal protein. B. Less than the pl of the normal protein. C. The same as the pl of the normal protein.
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