Based on this alignment, you can identify areas of the protein sequences that are key regions of the proteins. If you were to design a targeted mutagenesis programme to try to disrupt the activity of the proteins in this current alignment as part of a research programme, which THREE amino acid sequence regions (motifs) would you target? List your sequence motifs in order of preference (number 1 being your most confident target). Explain your reasoning for each motif
Based on this alignment, you can identify areas of the protein sequences that are key regions of the proteins. If you were to design a targeted mutagenesis programme to try to disrupt the activity of the proteins in this current alignment as part of a research programme, which THREE amino acid sequence regions (motifs) would you target? List your sequence motifs in order of preference (number 1 being your most confident target). Explain your reasoning for each motif
Biology Today and Tomorrow without Physiology (MindTap Course List)
5th Edition
ISBN:9781305117396
Author:Cecie Starr, Christine Evers, Lisa Starr
Publisher:Cecie Starr, Christine Evers, Lisa Starr
Chapter7: Gene Expression And Control
Section: Chapter Questions
Problem 2VQ
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Question
Based on this alignment, you can identify areas of the protein sequences that are key regions of the proteins. If you were to design a targeted mutagenesis programme to try to disrupt the activity of the proteins in this current alignment as part of a research programme, which THREE amino acid sequence regions (motifs) would you target? List your sequence motifs in order of preference (number 1 being your most confident target). Explain your reasoning for each motif
![CLUSTAL O (1.2.4) multiple sequence alignment
SEQUENCE_15
SEQUENCE_20
SEQUENCE 13
SEQUENCE_12
SEQUENCE 14
SEQUENCE 16
SEQUENCE 18
SEQUENCE_19
SEQUENCE 11
SEQUENCE 17
-MSRSGKSLTKYKIVFLGEQGVGKTSLITRFMYDTFDDHYQATIGIDF
47
MIVKLLQEIQVAQNTEEYDMEATIKVVLLGDSSVGKTSIVTRLKSGKFLAKHAATIGAAF
60
--MLQFKLVLLGDSSVGKSSIVHRFVKDTFDELRESTIGAAF
40
-MNTSVTSIKLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAF
44
-MDKHTAAIPTLTIKVVLLGESAVGKSSIVLRFVSDDFKESKEPTIGAAF
49
-M--SSRKKNILKVIILGDSGVGKTSLMHRYVNDKYSQQYKATIGADF
45
-MSSEDY--GYDYDLLFKIVLIGDSGVGKSNLLSRFTKNEFNMDSKSTIGVEF
50
-MSNEDY--GYDYDYLFKIVLIGDSGVGKSNLLSRFTTDEFNIESKSTIGVEF
50
-M--NSEYDYLFKLLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDF
45
-MSGLRTVSASSGN--GKSYDSIMKILLIGDSGVGKSCLLVRFVEDKFNPSFITTIGIDF
57
*::::*: ,***: :: *
• :
***
SEQUENCE_15
SEQUENCE 20
LSKTMYLD-
98
-DKTI-RLQLWDTAGQERFRSLIPSYIRDSRVAIIVYDITKRKSF
ITKTIEVPSNDSS--TEKRI-HMEIWDTAGQERYKSLVPMYYRDANIALIVFELGDVSSL
117
SEQUENCE_13
SEQUENCE_12
SEQUENCE_14
SEQUENCE_16
SEQUENCE 18
SEQUENCE 19
SEQUENCE_11
SEQUENCE 17
LSQSITIHPNDGNETKDVVI-KFEIWDTAGQERYKSLAPMYYRNANAALVVYDITQEDSL
99
LTQRVTIN---
--EHTV-KFEIWDTAGQERFASLAPMYYRNAQAALVVYDVTKPQSF
95
LTKRITRD-
-GKVI-KFEIWDTAGQERFAPLAPMYYRNAQAALVVFDVTNEGSF
100
-GDKVATMQVWDTAGQERFQSLGVAFYRGADCCVLVYDVTNASSF
-GKRI-KAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSY
-NKKI-KAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSY
LTKEVTVD-
97
ATRTLEID-
101
ATRTIEVE-
101
KIKTVELD-
-GKTV-KLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESF
96
ΚΙKTVDIN-
GKKV-KLQLWDTAGQERFRTITTAYYRGAMGIILVYDVTDERTF
108
: :
::********:
: *.:
::*:::
SEQUENCE 15
SEQUENCE 20
SEQUENCE 13
SEQUENCE 12
SEQUENCE 14
SEQUENCE 16
SEQUENCE 18
SEQUENCE_19
SEQUENCE_11
SEQUENCE 17
EYIDKWIEDVKNERGD--
-ENVILCIVGNKSDLSDERQ-
-IS
135
152
QCAKTWFQDLQDRAQG---TQ--VIIVGNKYDLVCEEHSG-
QKARNWVDELKNKVGD--
156
-DDLVIYLLGNKVDLCQETPSTETSPDSNEGGDEEQKVRAIS
--DIIIALVGNKIDMLQEGG-
IKARHWVKELHEQASK-
ERK---VA
134
YKAQNWVEELHEKVGH----DIVIALVGNKMDLLNNDD-
EΕΝENRΑMΚ
142
ENIKSWRDEFLVHANVNSPETFPFVILGNKIDAEESKK-
-IVS
138
ENCNHWLSELRENADD----NVAVGLIGNKSDLAHLRA-
-V-P
137
ENCNHWLTELRENADD--
-NVAVGLIGNKSDLAHLRA-
-V-P
137
NGVKMWLQEIDRYATS-
-TVLKLLVGNKCDLKDKR-
-V-E
132
TNIKQWFKTVNEHAND----EAQLLLVGNKSDMET-RV-
V-T
143
:: 大
SEQUENCE_15
SEQUENCE_20
SEQUENCE 13
SEQUENCE 12
SEQUENCE 14
TEEGEKKAKLLGAKIFMETSTKAGYNVKALFKKIAKSLPEFQNSESTPLDSEN----ANS
191
--EVTIPAEL-QGLPYVAVSAKTGYNFDTLNKIIISLVPESQFK-TLSKNNE-
200
TEEAKQYAQE-QGLLFREVSAKTGEGVKEIFQDIGEKLYDLKKDEILSKONRQ-
-IGG
211
187
REEGEKLAEE-KGLLFFETSAKTGENVNDVFLGIGEKIPLKTAEEQNSASNE-
APAVQNLCER-ENLLYFEASAKTGENIYQIFQTLGEKVPCPEQNTRQSSTHD-
--RE
-RTI
196
SEQUENCE 16
SEQUENCE 18
SEQUENCE_19
SEQUENCE_1i
SEQUENCE 17
EKSAQELAKSLGDIPLFLTSAKNAINVDTAFEEIARSALQQNQADTEAFEDD-
190
TEESKTFAQE-NQLLFTETSALNSENVDKAFEELINTIYQKVSKHQMDLGDSSANGNANG
196
195
TDEAKNFAME-NQMLFTETSALNSDNVDKAFRELIVAIFQMVSKHQVDLSGSGTN-NMGS
YDVAKEFADA-NKMPFLETSALDSTNVEDAFLTMARQIKESMSQQNLNETTQKK-
185
ADQGEALAKE-LGIPFIESSAKNDDNVNEIFFTLAKLIQEKIDSNKLVGVGNG-
195
*:
SEQUENCE 15
SEQUENCE 20
215
A-NQNKPGVIDIS-TAEEQEQSACQC-
--QG--NILE-INKKKSGSGCIC-
218
SEQUENCE 13
G-NNGQVDINLQR-PSTNDPTSCCS--
234
SEQUENCE 12
SEQUENCE 14
SEQUENCE_16
SEQUENCE_18
SEQUENCE_19
SEQUENCE_11
SEQUENCE 17
S-NNQRVDLNAAN--DGTSANSACSC-
210
T-DNQRIDLESTT-VESTRETGGCNC-
220
--YNDAINIRLDG--
ENNSCSC-
208
ASAPNGPTISLTPTPNENKKANGNNCC
223
NGAPKGPTISLTPAPKEDKKKKSSNCC
222
---EDKGNVNLKG---QSLTNTGGGCC
206
----KEGNISINS---GSGNSSKSNCC
215](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Febd908d2-12c5-44b3-abe2-553eb8cb49ca%2Fc58b7d7d-1290-4c7b-9a9d-61092c256c1e%2F2o15av9_processed.png&w=3840&q=75)
Transcribed Image Text:CLUSTAL O (1.2.4) multiple sequence alignment
SEQUENCE_15
SEQUENCE_20
SEQUENCE 13
SEQUENCE_12
SEQUENCE 14
SEQUENCE 16
SEQUENCE 18
SEQUENCE_19
SEQUENCE 11
SEQUENCE 17
-MSRSGKSLTKYKIVFLGEQGVGKTSLITRFMYDTFDDHYQATIGIDF
47
MIVKLLQEIQVAQNTEEYDMEATIKVVLLGDSSVGKTSIVTRLKSGKFLAKHAATIGAAF
60
--MLQFKLVLLGDSSVGKSSIVHRFVKDTFDELRESTIGAAF
40
-MNTSVTSIKLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAF
44
-MDKHTAAIPTLTIKVVLLGESAVGKSSIVLRFVSDDFKESKEPTIGAAF
49
-M--SSRKKNILKVIILGDSGVGKTSLMHRYVNDKYSQQYKATIGADF
45
-MSSEDY--GYDYDLLFKIVLIGDSGVGKSNLLSRFTKNEFNMDSKSTIGVEF
50
-MSNEDY--GYDYDYLFKIVLIGDSGVGKSNLLSRFTTDEFNIESKSTIGVEF
50
-M--NSEYDYLFKLLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDF
45
-MSGLRTVSASSGN--GKSYDSIMKILLIGDSGVGKSCLLVRFVEDKFNPSFITTIGIDF
57
*::::*: ,***: :: *
• :
***
SEQUENCE_15
SEQUENCE 20
LSKTMYLD-
98
-DKTI-RLQLWDTAGQERFRSLIPSYIRDSRVAIIVYDITKRKSF
ITKTIEVPSNDSS--TEKRI-HMEIWDTAGQERYKSLVPMYYRDANIALIVFELGDVSSL
117
SEQUENCE_13
SEQUENCE_12
SEQUENCE_14
SEQUENCE_16
SEQUENCE 18
SEQUENCE 19
SEQUENCE_11
SEQUENCE 17
LSQSITIHPNDGNETKDVVI-KFEIWDTAGQERYKSLAPMYYRNANAALVVYDITQEDSL
99
LTQRVTIN---
--EHTV-KFEIWDTAGQERFASLAPMYYRNAQAALVVYDVTKPQSF
95
LTKRITRD-
-GKVI-KFEIWDTAGQERFAPLAPMYYRNAQAALVVFDVTNEGSF
100
-GDKVATMQVWDTAGQERFQSLGVAFYRGADCCVLVYDVTNASSF
-GKRI-KAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSY
-NKKI-KAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSY
LTKEVTVD-
97
ATRTLEID-
101
ATRTIEVE-
101
KIKTVELD-
-GKTV-KLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESF
96
ΚΙKTVDIN-
GKKV-KLQLWDTAGQERFRTITTAYYRGAMGIILVYDVTDERTF
108
: :
::********:
: *.:
::*:::
SEQUENCE 15
SEQUENCE 20
SEQUENCE 13
SEQUENCE 12
SEQUENCE 14
SEQUENCE 16
SEQUENCE 18
SEQUENCE_19
SEQUENCE_11
SEQUENCE 17
EYIDKWIEDVKNERGD--
-ENVILCIVGNKSDLSDERQ-
-IS
135
152
QCAKTWFQDLQDRAQG---TQ--VIIVGNKYDLVCEEHSG-
QKARNWVDELKNKVGD--
156
-DDLVIYLLGNKVDLCQETPSTETSPDSNEGGDEEQKVRAIS
--DIIIALVGNKIDMLQEGG-
IKARHWVKELHEQASK-
ERK---VA
134
YKAQNWVEELHEKVGH----DIVIALVGNKMDLLNNDD-
EΕΝENRΑMΚ
142
ENIKSWRDEFLVHANVNSPETFPFVILGNKIDAEESKK-
-IVS
138
ENCNHWLSELRENADD----NVAVGLIGNKSDLAHLRA-
-V-P
137
ENCNHWLTELRENADD--
-NVAVGLIGNKSDLAHLRA-
-V-P
137
NGVKMWLQEIDRYATS-
-TVLKLLVGNKCDLKDKR-
-V-E
132
TNIKQWFKTVNEHAND----EAQLLLVGNKSDMET-RV-
V-T
143
:: 大
SEQUENCE_15
SEQUENCE_20
SEQUENCE 13
SEQUENCE 12
SEQUENCE 14
TEEGEKKAKLLGAKIFMETSTKAGYNVKALFKKIAKSLPEFQNSESTPLDSEN----ANS
191
--EVTIPAEL-QGLPYVAVSAKTGYNFDTLNKIIISLVPESQFK-TLSKNNE-
200
TEEAKQYAQE-QGLLFREVSAKTGEGVKEIFQDIGEKLYDLKKDEILSKONRQ-
-IGG
211
187
REEGEKLAEE-KGLLFFETSAKTGENVNDVFLGIGEKIPLKTAEEQNSASNE-
APAVQNLCER-ENLLYFEASAKTGENIYQIFQTLGEKVPCPEQNTRQSSTHD-
--RE
-RTI
196
SEQUENCE 16
SEQUENCE 18
SEQUENCE_19
SEQUENCE_1i
SEQUENCE 17
EKSAQELAKSLGDIPLFLTSAKNAINVDTAFEEIARSALQQNQADTEAFEDD-
190
TEESKTFAQE-NQLLFTETSALNSENVDKAFEELINTIYQKVSKHQMDLGDSSANGNANG
196
195
TDEAKNFAME-NQMLFTETSALNSDNVDKAFRELIVAIFQMVSKHQVDLSGSGTN-NMGS
YDVAKEFADA-NKMPFLETSALDSTNVEDAFLTMARQIKESMSQQNLNETTQKK-
185
ADQGEALAKE-LGIPFIESSAKNDDNVNEIFFTLAKLIQEKIDSNKLVGVGNG-
195
*:
SEQUENCE 15
SEQUENCE 20
215
A-NQNKPGVIDIS-TAEEQEQSACQC-
--QG--NILE-INKKKSGSGCIC-
218
SEQUENCE 13
G-NNGQVDINLQR-PSTNDPTSCCS--
234
SEQUENCE 12
SEQUENCE 14
SEQUENCE_16
SEQUENCE_18
SEQUENCE_19
SEQUENCE_11
SEQUENCE 17
S-NNQRVDLNAAN--DGTSANSACSC-
210
T-DNQRIDLESTT-VESTRETGGCNC-
220
--YNDAINIRLDG--
ENNSCSC-
208
ASAPNGPTISLTPTPNENKKANGNNCC
223
NGAPKGPTISLTPAPKEDKKKKSSNCC
222
---EDKGNVNLKG---QSLTNTGGGCC
206
----KEGNISINS---GSGNSSKSNCC
215
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