Based on this alignment, you can identify areas of the protein sequences that are key regions of the proteins. If you were to design a targeted mutagenesis programme to try to disrupt the activity of the proteins in this current alignment as part of a research programme, which THREE amino acid sequence regions (motifs) would you target? List your sequence motifs in order of preference (number 1 being your most confident target). Explain your reasoning for each motif CLUSTAL O (1.2.4) multiple sequence alignmentSEQUENCE_15SEQUENCE_20SEQUENCE 13SEQUENCE_12SEQUENCE 14SEQUENCE 16SEQUENCE 18SEQUENCE_19SEQUENCE 11SEQUENCE 17-MSRSGKSLTKYKIVFLGEQGVGKTSLITRFMYDTFDDHYQATIGIDF47MIVKLLQEIQVAQNTEEYDMEATIKVVLLGDSSVGKTSIVTRLKSGKFLAKHAATIGAAF60--MLQFKLVLLGDSSVGKSSIVHRFVKDTFDELRESTIGAAF40-MNTSVTSIKLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAF44-MDKHTAAIPTLTIKVVLLGESAVGKSSIVLRFVSDDFKESKEPTIGAAF49-M--SSRKKNILKVIILGDSGVGKTSLMHRYVNDKYSQQYKATIGADF45-MSSEDY--GYDYDLLFKIVLIGDSGVGKSNLLSRFTKNEFNMDSKSTIGVEF50-MSNEDY--GYDYDYLFKIVLIGDSGVGKSNLLSRFTTDEFNIESKSTIGVEF50-M--NSEYDYLFKLLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDF45-MSGLRTVSASSGN--GKSYDSIMKILLIGDSGVGKSCLLVRFVEDKFNPSFITTIGIDF57*::::*: ,***: :: *• :***SEQUENCE_15SEQUENCE 20LSKTMYLD-98-DKTI-RLQLWDTAGQERFRSLIPSYIRDSRVAIIVYDITKRKSFITKTIEVPSNDSS--TEKRI-HMEIWDTAGQERYKSLVPMYYRDANIALIVFELGDVSSL117SEQUENCE_13SEQUENCE_12SEQUENCE_14SEQUENCE_16SEQUENCE 18SEQUENCE 19SEQUENCE_11SEQUENCE 17LSQSITIHPNDGNETKDVVI-KFEIWDTAGQERYKSLAPMYYRNANAALVVYDITQEDSL99LTQRVTIN-----EHTV-KFEIWDTAGQERFASLAPMYYRNAQAALVVYDVTKPQSF95LTKRITRD--GKVI-KFEIWDTAGQERFAPLAPMYYRNAQAALVVFDVTNEGSF100-GDKVATMQVWDTAGQERFQSLGVAFYRGADCCVLVYDVTNASSF-GKRI-KAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSY-NKKI-KAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSYLTKEVTVD-97ATRTLEID-101ATRTIEVE-101KIKTVELD--GKTV-KLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESF96ΚΙKTVDIN-GKKV-KLQLWDTAGQERFRTITTAYYRGAMGIILVYDVTDERTF108: :::********:: *.:::*:::SEQUENCE 15SEQUENCE 20SEQUENCE 13SEQUENCE 12SEQUENCE 14SEQUENCE 16SEQUENCE 18SEQUENCE_19SEQUENCE_11SEQUENCE 17EYIDKWIEDVKNERGD---ENVILCIVGNKSDLSDERQ--IS135152QCAKTWFQDLQDRAQG---TQ--VIIVGNKYDLVCEEHSG-QKARNWVDELKNKVGD--156-DDLVIYLLGNKVDLCQETPSTETSPDSNEGGDEEQKVRAIS--DIIIALVGNKIDMLQEGG-IKARHWVKELHEQASK-ERK---VA134YKAQNWVEELHEKVGH----DIVIALVGNKMDLLNNDD-EΕΝENRΑMΚ142ENIKSWRDEFLVHANVNSPETFPFVILGNKIDAEESKK--IVS138ENCNHWLSELRENADD----NVAVGLIGNKSDLAHLRA--V-P137ENCNHWLTELRENADD---NVAVGLIGNKSDLAHLRA--V-P137NGVKMWLQEIDRYATS--TVLKLLVGNKCDLKDKR--V-E132TNIKQWFKTVNEHAND----EAQLLLVGNKSDMET-RV-V-T143:: 大SEQUENCE_15SEQUENCE_20SEQUENCE 13SEQUENCE 12SEQUENCE 14TEEGEKKAKLLGAKIFMETSTKAGYNVKALFKKIAKSLPEFQNSESTPLDSEN----ANS191--EVTIPAEL-QGLPYVAVSAKTGYNFDTLNKIIISLVPESQFK-TLSKNNE-200TEEAKQYAQE-QGLLFREVSAKTGEGVKEIFQDIGEKLYDLKKDEILSKONRQ--IGG211187REEGEKLAEE-KGLLFFETSAKTGENVNDVFLGIGEKIPLKTAEEQNSASNE-APAVQNLCER-ENLLYFEASAKTGENIYQIFQTLGEKVPCPEQNTRQSSTHD---RE-RTI196SEQUENCE 16SEQUENCE 18SEQUENCE_19SEQUENCE_1iSEQUENCE 17EKSAQELAKSLGDIPLFLTSAKNAINVDTAFEEIARSALQQNQADTEAFEDD-190TEESKTFAQE-NQLLFTETSALNSENVDKAFEELINTIYQKVSKHQMDLGDSSANGNANG196195TDEAKNFAME-NQMLFTETSALNSDNVDKAFRELIVAIFQMVSKHQVDLSGSGTN-NMGSYDVAKEFADA-NKMPFLETSALDSTNVEDAFLTMARQIKESMSQQNLNETTQKK-185ADQGEALAKE-LGIPFIESSAKNDDNVNEIFFTLAKLIQEKIDSNKLVGVGNG-195*:SEQUENCE 15SEQUENCE 20215A-NQNKPGVIDIS-TAEEQEQSACQC---QG--NILE-INKKKSGSGCIC-218SEQUENCE 13G-NNGQVDINLQR-PSTNDPTSCCS--234SEQUENCE 12SEQUENCE 14SEQUENCE_16SEQUENCE_18SEQUENCE_19SEQUENCE_11SEQUENCE 17S-NNQRVDLNAAN--DGTSANSACSC-210T-DNQRIDLESTT-VESTRETGGCNC-220--YNDAINIRLDG--ENNSCSC-208ASAPNGPTISLTPTPNENKKANGNNCC223NGAPKGPTISLTPAPKEDKKKKSSNCC222---EDKGNVNLKG---QSLTNTGGGCC206----KEGNISINS---GSGNSSKSNCC215

Name: Based on this alignment, you can identify areas of the protein sequenc
Uploaded: 2024-03-20T06:42:55.000Z
Channel: Bartleby
Description: Based on this alignment, you can identify areas of the protein sequences that are key regions of the proteins. If you were to design a targeted mutagenesis programme to try to disrupt the activity of the proteins in this current alignment as part of