Mutational signatures of p53 are shown in this image (G.P. Pfeifer et al., Nature, 21(48), 2002) for the three types of cancer with the highest death rates in the United States: lung (~225,000 deaths in 2016), breast (246,000), and colorectal (381,000). These data can be obtained by sequencing the gene that encodes p53. Approximately 85 percent of lung cancers occur in smokers. Based on these data, calculate how many deaths due to lung cancer among nonsmokers were reported in 2016

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Mutational signatures of p53 are shown in this image (G.P. Pfeifer et al., Nature, 21(48), 2002) for the three types of cancer with the highest death rates in the United States: lung (~225,000 deaths in 2016), breast (246,000), and colorectal (381,000). These data can be obtained by sequencing the gene that encodes p53. Approximately 85 percent of lung cancers occur in smokers. Based on these data, calculate how many deaths due to lung cancer among nonsmokers were reported in 2016. How much does smoking increase the likelihood of death due to lung cancer?
Mutational Signatures of p53 for
Three Types of Cancer
Nonsmoker's lungs
11% 12%
47%
29%
Smoker's lungs
11%
4%
54%
12%
4%
10% 4%
10%
6% 9%
5%
30%
Breast and colorectal cancer
12%
13%
4%
3%
11%
G:CT:A
G:CA:T
G:C C:G
A:TC:G A:TG:C A:TT:A
Deletion/insertion
Transcribed Image Text:Mutational Signatures of p53 for Three Types of Cancer Nonsmoker's lungs 11% 12% 47% 29% Smoker's lungs 11% 4% 54% 12% 4% 10% 4% 10% 6% 9% 5% 30% Breast and colorectal cancer 12% 13% 4% 3% 11% G:CT:A G:CA:T G:C C:G A:TC:G A:TG:C A:TT:A Deletion/insertion
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