Homework Help is Here – Start Your Trial Now!
Science
Biology
Methods Microarray chip with DNA probes A microarray consists of DNA probes fixed to a sold support, such as a nylon membrane or glass side Each spot consists of a different DNA probe. Hybridization Cancer cells CDNA with RNA fluorescent bases Noncancer cells 3Cancer and O The CDNAS 7 and hybridized 8 The chip is scanned spot by spot. Yelow fluorescence (red + green) indicates equal expression of the gene in both types of cells; red indicates more expression in cancer cells; and green indicates more expression in noncancer cells. 4 Messenger RNA B is converted into from the cels... are moxed.. to DNA probes on a chip. noncancer cells are removed from 78 wormen with breast cancer. CONA and labeled with red (cancer cels) or green (noncancer cells) fluorescent nucleotides. Results Each spot represents the expression of one gene in one patient's tumor compared with the expression of that gene in her noncancer cells. Tumors above the solid yellow line came primarily from patients who remained cancer free for at least 5 years. Tumors below the solid yellow line came primarily from patients in whom the cancer spréad within 5 years of diagnosis. 20.10 Microarrays can be used to examine gene expression associated with disease progression.

Methods Microarray chip with DNA probes A microarray consists of DNA probes fixed to a sold support, such as a nylon membrane or glass side Each spot consists of a different DNA probe. Hybridization Cancer cells CDNA with RNA fluorescent bases Noncancer cells 3Cancer and O The CDNAS 7 and hybridized 8 The chip is scanned spot by spot. Yelow fluorescence (red + green) indicates equal expression of the gene in both types of cells; red indicates more expression in cancer cells; and green indicates more expression in noncancer cells. 4 Messenger RNA B is converted into from the cels... are moxed.. to DNA probes on a chip. noncancer cells are removed from 78 wormen with breast cancer. CONA and labeled with red (cancer cels) or green (noncancer cells) fluorescent nucleotides. Results Each spot represents the expression of one gene in one patient's tumor compared with the expression of that gene in her noncancer cells. Tumors above the solid yellow line came primarily from patients who remained cancer free for at least 5 years. Tumors below the solid yellow line came primarily from patients in whom the cancer spréad within 5 years of diagnosis. 20.10 Microarrays can be used to examine gene expression associated with disease progression.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
icon
Concept explainers
Question

Of the genes in the microarray shown in the lower part of Figure 20.10, are most overexpressed or underexpressed in tumors from patients that remained cancer free for at least five years? Explain your reasoning.

Methods Microarray chip with DNA probes A microarray consists of DNA probes fixed to a sold support, such as a nylon membrane or glass side Each spot consists of a different DNA probe. Hybridization Cancer cells CDNA with RNA fluorescent bases Noncancer cells 3Cancer and O The CDNAS 7 and hybridized 8 The chip is scanned spot by spot. Yelow fluorescence (red + green) indicates equal expression of the gene in both types of cells; red indicates more expression in cancer cells; and green indicates more expression in noncancer cells. 4 Messenger RNA B is converted into from the cels... are moxed.. to DNA probes on a chip. noncancer cells are removed from 78 wormen with breast cancer. CONA and labeled with red (cancer cels) or green (noncancer cells) fluorescent nucleotides. Results Each spot represents the expression of one gene in one patient's tumor compared with the expression of that gene in her noncancer cells. Tumors above the solid yellow line came primarily from patients who remained cancer free for at least 5 years. Tumors below the solid yellow line came primarily from patients in whom the cancer spréad within 5 years of diagnosis. 20.10 Microarrays can be used to examine gene expression associated with disease progression.
Transcribed Image Text:Methods Microarray chip with DNA probes A microarray consists of DNA probes fixed to a sold support, such as a nylon membrane or glass side Each spot consists of a different DNA probe. Hybridization Cancer cells CDNA with RNA fluorescent bases Noncancer cells 3Cancer and O The CDNAS 7 and hybridized 8 The chip is scanned spot by spot. Yelow fluorescence (red + green) indicates equal expression of the gene in both types of cells; red indicates more expression in cancer cells; and green indicates more expression in noncancer cells. 4 Messenger RNA B is converted into from the cels... are moxed.. to DNA probes on a chip. noncancer cells are removed from 78 wormen with breast cancer. CONA and labeled with red (cancer cels) or green (noncancer cells) fluorescent nucleotides. Results Each spot represents the expression of one gene in one patient's tumor compared with the expression of that gene in her noncancer cells. Tumors above the solid yellow line came primarily from patients who remained cancer free for at least 5 years. Tumors below the solid yellow line came primarily from patients in whom the cancer spréad within 5 years of diagnosis. 20.10 Microarrays can be used to examine gene expression associated with disease progression.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Cancer therapy
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS