In many types of tumors, the genomic DNA methylation pattern is changed either through hypermethylation (increased methylation) or hypomethylation (decreased methylation). Particularly, hypermethylation of CpG islands in the promoter region of some driver genes is associated with aberrant silencing of transcription in cancer cells. DNA methylation is regulated by two enzymes with opposing activities: DNA demethylation mediated by TET and re-methylation by DNMT. What would be a potential cancer therapy that can restore the expression of these driver genes? ODNMT inhibitor Delivery of TET protein to hypermethylated driver genes OTET inhibitor OsiRNA targeted to TET gene OsiRNA targeted to DNMT gene Delivery of DNMT protein to hypermethylated driver genes

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Proteins

We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.  

Protein Expression

The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.