Chapter 8.8, Problem 8.21TIY

(a)

Interpretation Introduction

Interpretation: The synthesis of $\text{2-methyl-2-propanol}$ from methane should be written.

Concept introduction: Retrosynthetic analysis involves transformation of target molecule into simple precursor that can be used as substrate for the synthesis of target molecule. The bonds broken generate molecules called synthons or synthetic equivalent. The latter term is designated to indicate their use as substrate in synthesis. For instance, the synthons generated in phenylacetic acid are given as follows:

  

The best approach to retrosynthetic analysis is to look for easily available reagents such as Grignard reagents.

(b)

Interpretation Introduction

Interpretation: The synthesis of $\text{3,4-dimethyl-3-hexanol}$ from butane should be written.

Concept introduction:Retrosynthetic analysis involves transformation of target molecule into simple precursor that can be used as substrate for the synthesis of target molecule. The bonds broken generate molecules called synthons or synthetic equivalent. The latter term is designated to indicate their use as substrate in synthesis. For instance, the synthons generated in phenylacetic acid are given as follows:

  

The best approach to the retrosynthetic analysis is to look for easily available reagents such as Grignard reagents.