ORGANIC CHEMISTRY (LL)-PACKAGE
ORGANIC CHEMISTRY (LL)-PACKAGE
8th Edition
ISBN: 9781319316389
Author: VOLLHARDT
Publisher: MAC HIGHER
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Chapter 8, Problem 56P
Interpretation Introduction

Interpretation:The missing reagent required in the synthetic transformation scheme indicated should be filled sequentially.

  ORGANIC CHEMISTRY (LL)-PACKAGE, Chapter 8, Problem 56P , additional homework tip  1

Concept introduction:Grignard reagents are alkyl magnesium halides obtained from the treatment of haloalkane with magnesium in the presence of dried ether conditions. This reagent isuseful precursor for the quick synthesis of a variety of organic compounds For example, the reaction of Grignard reagent with aldehyde or ketone generates alcohol as illustrated below.

  ORGANIC CHEMISTRY (LL)-PACKAGE, Chapter 8, Problem 56P , additional homework tip  2

Methyl bromide reacts with magnesium ether to give Grignard reagent. This Grignard methyl magnesium bromide on treatment with formaldehyde gives corresponding alcohol. The mechanistic pathway for the latter reaction is as follows:

  ORGANIC CHEMISTRY (LL)-PACKAGE, Chapter 8, Problem 56P , additional homework tip  3

The polar carbonyl bond breaks and the polar Grignard reagent attack at electron-deficient carbon. Finally with the hydrolysis and work up the alcohol is formed.

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