Biology: The Unity and Diversity of Life (MindTap Course List)
14th Edition
ISBN: 9781305073951
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 7, Problem 3DAA
Mitochondrial Abnormalities in Tetralogy of Fallot Tetralogy of Fallot (TF) is a genetic disorder in which heart malformations result in abnormal blood circulation, so oxygen does not reach body cells as it should. With insufficient oxygen to accept electrons at the end of miotchondrial electron transfer chains, too many free radicals form. This damages the mitochondria—and the cells. In 2004, Sarah Kuruvilla studied mitochondria in the heart muscle of TF patients. Some of her results are shown in FIGURE 7.13.
| Patient (age) | SPO2(%) | Mitochondrial Abnormalities in TF | |||
| Number | Shape | Size | Broken | ||
| 1(5) | 55 | + | + | − | − |
| 2(3) | 69 | + | + | − | − |
| 3(22) | 72 | + | + | − | − |
| 4(2) | 74 | + | + | − | − |
| 5(3) | 76 | + | + | − | + |
| 6(2.5) | 78 | + | + | − | + |
| 7(1) | 79 | + | + | − | − |
| 8(12) | 80 | + | − | + | − |
| 9(4) | 80 | + | + | − | − |
| 10(B) | 83 | + | − | + | − |
| 11(20) | 85 | + | + | − | − |
| 12(2.5) | 89 | + | − | + | − |
FIGURE 7.13 Mitochondrial changes in tetralogy of Fallot (TF).
(A) Normal heart muscle. Many mitochondria between the fibers provide muscle cells with ATP for contraction. (B) Heart muscle from a person with TF has swollen, broken mitochondria.
(C) Types of mitochondrial abnormalities in TF patients. SPO2 is oxygen saturation of the blood. A normal value of SPO2 is 96%. Abnormalities are marked +.
3. Can you make any correlations between blood oxygen content and mitochondrial abnormalities in these patients?
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Chapter 7 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 7 - Is the following statement true or false? Unlike...Ch. 7 - Glycolysis starts and ends in the ___. a. nucleus...Ch. 7 - Which of the following metabolic pathways...Ch. 7 - Which molecule does not form during glycolysis? a....Ch. 7 - Prob. 5SQCh. 7 - Which of the following reaction pathways is not...Ch. 7 - Prob. 7SQCh. 7 - Prob. 8SQCh. 7 - Prob. 9SQCh. 7 - Mitochondrial Abnormalities in Tetralogy of Fallot...
Ch. 7 - Mitochondrial Abnormalities in Tetralogy of Fallot...Ch. 7 - Mitochondrial Abnormalities in Tetralogy of Fallot...Ch. 7 - Prob. 10SQCh. 7 - Most of the energy that aerobic respiration...Ch. 7 - Prob. 12SQCh. 7 - Prob. 13SQCh. 7 - Prob. 14SQCh. 7 - Match the term with the best description. _____...Ch. 7 - Prob. 1CTCh. 7 - As you learned, membranes impermeable to hydrogen...Ch. 7 - Prob. 3CT
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