Biology: The Unity and Diversity of Life (MindTap Course List)
14th Edition
ISBN: 9781305073951
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 7, Problem 1DAA
Mitochondrial Abnormalities in Tetralogy of Fallot Tetralogy of Fallot (TF) is a genetic disorder in which heart malformations result in abnormal blood circulation, so oxygen does not reach body cells as it should. With insufficient oxygen to accept electrons at the end of miotchondrial electron transfer chains, too many free radicals form. This damages the mitochondria—and the cells. In 2004, Sarah Kuruvilla studied mitochondria in the heart muscle of TF patients. Some of her results are shown in FIGURE 7.13.
| Patient (age) | SPO2(%) | Mitochondrial Abnormalities in TF | |||
| Number | Shape | Size | Broken | ||
| 1(5) | 55 | + | + | − | − |
| 2(3) | 69 | + | + | − | − |
| 3(22) | 72 | + | + | − | − |
| 4(2) | 74 | + | + | − | − |
| 5(3) | 76 | + | + | − | + |
| 6(2.5) | 78 | + | + | − | + |
| 7(1) | 79 | + | + | − | − |
| 8(12) | 80 | + | − | + | − |
| 9(4) | 80 | + | + | − | − |
| 10(B) | 83 | + | − | + | − |
| 11(20) | 85 | + | + | − | − |
| 12(2.5) | 89 | + | − | + | − |
FIGURE 7.13 Mitochondrial changes in tetralogy of Fallot (TF).
(A) Normal heart muscle. Many mitochondria between the fibers provide muscle cells with ATP for contraction. (B) Heart muscle from a person with TF has swollen, broken mitochondria.
(C) Types of mitochondrial abnormalities in TF patients. SPO2 is oxygen saturation of the blood. A normal value of SPO2 is 96%. Abnormalities are marked +.
1. In this study, which abnormality was most strongly associated with TF?
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. Aerobic respiration, used by the mitochondria of eukaryotic cells, is best represented by which of the following balanced equations?
6CO2 + 12H2S g C6H12O6 + 6S2 + 6H2O
C6H12O6 + 6O2 + 6H2O g 6CO2 + 12H2O
C12H22O11 + H2O g C6H12O6 + C6H12O6
6CO2 + 12H2O g C6H12O6 + 6O2 + 6H2O
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19- Cyanide inhibits cytochrome c oxidase, a
component of the electron transport chain. If cyanide
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intermembrane space to increase or decrease? What
effect would cyanide have on ATP synthesis?
20. Because they lose their mitochondria
during development, red blood cells cannot
perform aerobic respiration; however, they do
perform glycolysis in the cytoplasm. Why do all
cells need an energy source, and what would
happen if glycolysis were blocked in a red
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Chapter 7 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 7 - Is the following statement true or false? Unlike...Ch. 7 - Glycolysis starts and ends in the ___. a. nucleus...Ch. 7 - Which of the following metabolic pathways...Ch. 7 - Which molecule does not form during glycolysis? a....Ch. 7 - Prob. 5SQCh. 7 - Which of the following reaction pathways is not...Ch. 7 - Prob. 7SQCh. 7 - Prob. 8SQCh. 7 - Prob. 9SQCh. 7 - Mitochondrial Abnormalities in Tetralogy of Fallot...
Ch. 7 - Mitochondrial Abnormalities in Tetralogy of Fallot...Ch. 7 - Mitochondrial Abnormalities in Tetralogy of Fallot...Ch. 7 - Prob. 10SQCh. 7 - Most of the energy that aerobic respiration...Ch. 7 - Prob. 12SQCh. 7 - Prob. 13SQCh. 7 - Prob. 14SQCh. 7 - Match the term with the best description. _____...Ch. 7 - Prob. 1CTCh. 7 - As you learned, membranes impermeable to hydrogen...Ch. 7 - Prob. 3CT
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- Mitochondrial Abnormalities in Tetralogy of Fallot Tetralogy of Fallot (TF) is a genetic disorder in which heart malformations result in abnormal blood circulation, so oxygen does not reach body cells as it should. With insufficient oxygen to accept electrons at the end of miotchondrial electron transfer chains, too many free radicals form. This damages the mitochondriaand the cells. In 2004, Sarah Kuruvilla studied mitochondria in the heart muscle of TF patients. Some of her results are shown in FIGURE 7.13. Patient (age) SPO2(%) Mitochondrial Abnormalities in TF Number Shape Size Broken 1(5) 55 + + 2(3) 69 + + 3(22) 72 + + 4(2) 74 + + 5(3) 76 + + + 6(2.5) 78 + + + 7(1) 79 + + 8(12) 80 + + 9(4) 80 + + 10(B) 83 + + 11(20) 85 + + 12(2.5) 89 + + FIGURE 7.13 Mitochondrial changes in tetralogy of Fallot (TF). (A) Normal heart muscle. Many mitochondria between the fibers provide muscle cells with ATP for contraction. (B) Heart muscle from a person with TF has swollen, broken mitochondria. (C) Types of mitochondrial abnormalities in TF patients. SPO2 is oxygen saturation of the blood. A normal value of SPO2 is 96%. Abnormalities are marked +. 2. What percentage of the TF patients had mitochondria that were abnormal in size?arrow_forwardProtein: complex I, Role: Complex I is the first enzyme complex involved in oxidizing NADH as part of the electron transport chain (ETC). The ETC is the penultimate step in cellular respiration occurring across the inner mitochondrial membrane. Where is this protein synthesized? Be as specific as possible and briefly explain your choicearrow_forwardMON TRANSPORT CHAIN Intermembrane Space 3 ACP Mitochondrial Matrix FADH FAD Copyrighs 0200n Benmin Cummings an impii s Addson identify the importance to keep the electrons (e-) running through the electron transport chain. The electrons move to and join with ADP to form ATP Electron movement causes the body to take in axygen. The electrons will flow through ATP Synthase in order to make ATP The energy of the moving electrons will power the transport of H+ to the intermembrane space. Next Previous 00arrow_forward
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