Biochemistry
Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 32, Problem 7P
Interpretation Introduction

Interpretation:

The acetylcholine concentration in the synaptic vesicle needs to be calculated.

Concept Introduction :

The shape of a vesicle is like the shape of a cylinder thus its volume can be calculated as follows:

  V=43πr3

Here, r is radius of the base of the cylinder.

The concentration is calculated as number of moles present in 1 L of the solution.

It is mathematically represented as follows:

  C=nV

From the given number of atoms, the number of moles can be calculated by dividing it with Avogadro’s number which is number of atoms in 1 mol of the substance.

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Myasthenia gravis is a disease that leads to a marked decrease in the number of acetylcholine (Ach) receptors at the neuromuscular junction.  As a result, suppose only about 200 (instead of 2000) Ach receptor-channels are opened by each quantum of Ach.  The Ach-gated channels that survive operate normally and each cause a depolarization of about 0.25 x 10-3 mV when open.  The function of the presynaptic terminal is normal and an action potential will cause the release of 100 quanta of neurotransmitter.  Part a.) For a patient with myasthenia gravis, what would be the size (in mV) of a miniature excitatory post-synaptic potential (or that associated with one quantum of Ach)? a.) 0.05 mv b.) 0.25x10-4 mv c.) 0.25x10-3 mv d.) 0.5x10-3 mv e.) 0.5 mv   Part b.) For a patient with myasthenia gravis, what would be the size (in mV) of the full excitatory post synaptic potential consequent to the entry of an action potential into the presynaptic terminal of the neuromuscular junction? a.) 70 mv…
Myasthenia gravis is a disease that leads to a marked decrease in the number of acetylcholine (Ach) receptors at the neuromuscular junction.  As a result, suppose only about 200 (instead of 2000) Ach receptor-channels are opened by each quantum of Ach.  The Ach-gated channels that survive operate normally and each cause a depolarization of about 0.25 x 10-3 mV when open.  The function of the presynaptic terminal is normal and an action potential will cause the release of 100 quanta of neurotransmitter. For a patient with myasthenia gravis, what would be the magnitude of the depolarization (in mV) associated with opening of one Ach-gated channel?  a.) 0.25x10^-2 mv b.) 0.25x10^-3 mv c.) 0.25x10^-4 mv d.) 0.5x10^-1 mv e.) 0.5 mv
Based on the same attached figure as in question 1 above (Figure 6.8A-B in your textbook) describing the NMDA receptor, a ligand-gated ion channel for glutamate, why does the current versus voltage response described by the red line go from near zero to a negative current at around -50 mV? (A) Channel pore Glutamate Mg2+ (B) EPSC (PA) 150 100 50 0 -50 -100 -150 Hyperpolarized, Mg2+ blocks ORA Glutamate + Mg2+ 0/ + Na Ca²+ Glutamate, no Mg2+ Depolarized, no Mg2+ block while K+ 100 Mg2+
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