Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 32, Problem 17P
Interpretation Introduction
Interpretation:
The effect on the cell signaling pathway due to mutation of Ras in order to have zero GTPase activity.
Concept Introduction :
Cell signaling directs elementary cellular actions and coordinates cell actions. Cell signaling might help diseases to be treated efficiently and treatments created.
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Explain why in cells that are genetically NF1–/–, basal levels of GTP-bound activated Ras are higher than normal and respond to growth factor stimulation by increasing rapidly to far higher levels.
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Referring to Figure 18.5, predict what would happen if the SRPRNA was unable to stimulate the GTPase activities of the GTPbindingproteins within SRP and the SRP receptor.
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- Compare and contrast GPCR and RTK signaling. What role does GTP play in each? What role does phosphorylation play? How do these two signaling types compare to steroid signaling with respect to gene activation?arrow_forwardCell signaling The maximum secretion rates of proteins are one type of limiting constraint on signal-ing processes since a cell cannot send a signal faster than it can secrete it. These maximum signalingrates can be estimated with maximum rates of transcription and translation. Consequently, proteins withstrong promoters can be synthesized at much higher rates. Immunoglobulins, which are important signal-ing molecules, have very strong promoters. Their maximum secretion rate is on the order of 2000 to 8000antibody molecules/cell/second, which corresponds to approximately 1 pg/cell/hr. Part AWhat would be the maximum signal (in pg/cell/hr) that a cell could send for the following situations: (1)Signal molecule A has a MW = 100,000 daltons and is secreted at a rate of 1000 molecules/cell/second. (2)Signal molecule B has a MW = 50,000 daltons and is secreted at 5000 molecules/cell/second.Part BWhich molecule is secreted at a higher rate? By how much?Part CIf equivalent fluxes of both…arrow_forwarda change that decreases the rate of hydrolysis of GTP by Ras a change that increases the affinity of Ras for GDP a change that decreases the affinity of Ras for GTP O a change that prevents Ras from being madearrow_forward
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