Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Question
Chapter 32, Problem 16P
Interpretation Introduction
Interpretation:
All the steps of the pathway involved in the signal amplification needs to be discussed.
Concept Introduction :
Cell signaling directs elementary cellular actions and coordinates cell actions. Cell signaling might help diseases to be treated efficiently and treatments created.
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Give a Detailed Solution with explanation needed (don't give Handwritten answer)
Signal Molecule- Somatostatin
Receptor Name- Somatostatin receptor type 2
Draw the structure of the signal molecule (for peptides just sketch key motifs the best you can; i.e. alpha helices and beta sheets)
discuss (100 words) the key features of the signaling cascade produced by reception of the signal molecule. along w/ 2-3 bullet points highlighting areas critical to signal amplification as well as basic mechanisms of signal termination. Cite one article
Pathway analysis: Link the protein names to the correct statements by interrogating the depicted pathway.
Options:
A.
RTK Receptor Threonine Kinase
B.
GEF Guanidine Exchange Factor
C.
PLC Phospholipase C
D.
GAP GTPase Activating Protein
E.
Gαi
F.
Raf Rapidly Accelerated Fibrosarcoma
G.
PAK1 p21 Activated Kinase
H.
WASP Wiscott Aldrich syndrome protein
I.
RTK Receptor Tyrosine Kinase
J.
GPCR G-protein Coupled Receptor
K.
Steroid Receptor
L.
Phosphatase
M.
MEK1 (Mitogen-Activated Protein) Kinase/ERK (Extracellular Signal-Regulated Kinase) Kinase 1
N.
AC Adenylyl cyclase
O.
IP3R IP3 Receptor
P.
ERK1/2 Extracellular Signal-Regulated Kinase
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