Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 32, Problem 18P
Interpretation Introduction
Interpretation:
The reason for the difficulty in verifying the G-protein independent signaling in the experiment needs to be explained.
Introduction:
Cell signaling directs elementary cellular actions and coordinates cell actions. Cell signaling might help diseases to be treated efficiently and treatments created.
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Working out the order in which the individual components in a signaling pathway act is an essential step in defining the pathway. Imagine that two protein kinases, PK1 and PK2, act sequentially in a kinase cascade. When either kinase is completely inactivated, cells do not respond to the normal extracellular signal. By contrast, cells containing a mutant form of PK1 that is permanently active respond even in the absence of an extracellular signal. Double mutant cells that contain inactivated PK2 and permanently active PK1 respond in the absence of a signal.
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