Precise quantification of smoking during pregnancy is difficult in retrospective studies. Routinely collected blood specimens from newborns for screening purposes may provide a low-cost method to objectively measure maternal smoking close to the time of delivery. Serum cotinine is an important biomarker of recent smoking. A study was performed comparing cotinine levels in dried blood spots in newborns with those in umbilical cord blood (the gold standard) among 428 newborns in the California Genetic Screening Program (Yang et al. [11]). The lowest detection limit for dried blood spot cotinine was 3.1 ng/mL. The data in Table 3.9 were presented relating dried blood spot cotinine determinations to umbilical cord blood cotinine determinations. Suppose a cutoff of ≥ 5 ng/mL is proposed as a criterion for testing positive based on dried blood spot cotinine levels. TABLE 3.9 Distribution of Cotinine Level in Dried Blood Spots from Newborns by Maternal Active Smoking Status* close to the time of delivery among 428 babies delivered in California, 2001–2003 What is the specificity using this cut-point?
Precise quantification of smoking during pregnancy is difficult in retrospective studies. Routinely collected blood specimens from newborns for screening purposes may provide a low-cost method to objectively measure maternal smoking close to the time of delivery. Serum cotinine is an important biomarker of recent smoking. A study was performed comparing cotinine levels in dried blood spots in newborns with those in umbilical cord blood (the gold standard) among 428 newborns in the California Genetic Screening Program (Yang et al. [11]). The lowest detection limit for dried blood spot cotinine was 3.1 ng/mL. The data in Table 3.9 were presented relating dried blood spot cotinine determinations to umbilical cord blood cotinine determinations. Suppose a cutoff of ≥ 5 ng/mL is proposed as a criterion for testing positive based on dried blood spot cotinine levels. TABLE 3.9 Distribution of Cotinine Level in Dried Blood Spots from Newborns by Maternal Active Smoking Status* close to the time of delivery among 428 babies delivered in California, 2001–2003 What is the specificity using this cut-point?
Solution Summary: The author explains that the specificity using the cut-point is 0.979.
Precise quantification of smoking during pregnancy is difficult in retrospective studies. Routinely collected blood specimens from newborns for screening purposes may provide a low-cost method to objectively measure maternal smoking close to the time of delivery. Serum cotinine is an important biomarker of recent smoking. A study was performed comparing cotinine levels in dried blood spots in newborns with those in umbilical cord blood (the gold standard) among 428 newborns in the California Genetic Screening Program (Yang et al. [11]). The lowest detection limit for dried blood spot cotinine was 3.1 ng/mL. The data in Table 3.9 were presented relating dried blood spot cotinine determinations to umbilical cord blood cotinine determinations.
Suppose a cutoff of ≥ 5 ng/mL is proposed as a criterion for testing positive based on dried blood spot cotinine levels.
TABLE 3.9 Distribution of Cotinine Level in Dried Blood Spots from Newborns by Maternal Active Smoking Status* close to the time of delivery among 428 babies delivered in California, 2001–2003
Find the critical value for a left-tailed test using the F distribution with a 0.025, degrees of freedom in the numerator=12, and degrees of freedom in the
denominator = 50. A portion of the table of critical values of the F-distribution is provided.
Click the icon to view the partial table of critical values of the F-distribution.
What is the critical value?
(Round to two decimal places as needed.)
A retail store manager claims that the average daily sales of the store are $1,500.
You aim to test whether the actual average daily sales differ significantly from this claimed value.
You can provide your answer by inserting a text box and the answer must include:
Null hypothesis,
Alternative hypothesis,
Show answer (output table/summary table), and
Conclusion based on the P value.
Showing the calculation is a must. If calculation is missing,so please provide a step by step on the answers
Numerical answers in the yellow cells
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