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Concept explainers
(a)
Interpretation:
The given structure is whether antihistamine or antidepressant has to be predicted.
Concept Introduction:
Drugs: Drugs are molecules which are taken from an external source to change the normal functioning of the body. The action of drug is in molecular level and the design of many drugs are in such a way that it mimics a particular neurotransmitter or hormone. Drugs bind with receptors showing an increased or decreased effect.
There are two types of drugs and they are agonist and antagonist.
Histamine: Histamines are the neurotransmitters which is responsible for causing symptoms of allergic reactions. The amino acid histidine undergoes decarboxylation reaction to produce histidine.
Antihistamines: Antihistamines are antagonist of the histamine receptors. They are the family of drugs which counteract the effects caused by histamine. Antihistamine has a general structure
(a)
Interpretation:
The given structure is whether antihistamine or antidepressant has to be predicted.
Concept Introduction:
Drugs: Drugs are molecules which are taken from an external source to change the normal functioning of the body. The action of drug is in molecular level and the design of many drugs are in such a way that it mimics a particular neurotransmitter or hormone. Drugs bind with receptors showing an increased or decreased effect.
There are two types of drugs and they are agonist and antagonist.
The deficiency of the neurotransmitters serotonin, norepinephrine and dopamine leads to depression.
By the mode of action, three families of drugs are used as effective anti-depressant. They are,
- 1. Tricyclic antidepressant (Elavil): It prevents the reabsorption of serotonin and norepinephrine from the inside of synapse
- 2. Monoamine oxidase (MAO) inhibitor (Nardil): It prevents the enzyme which breaks down serotonin, norepinephrine and dopamine
- 3. Selective serotonin re-uptake inhibitors, SSRI (Prozac): It prevents the reabsorption of serotonin alone
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Chapter 28 Solutions
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- Pls help with these three questionsarrow_forward11. Which of the compounds below is the major product of the following reaction sequence? NOTE: PCC is pyridinium chlorochromate 1. BH 3 PCC 2. H2O2, NaOH NH HN ΗΝ, A B C CH3NH2, NaBH3CN D E NHarrow_forward10. Which of the compounds below is the major organic product obtained from the following reaction sequence? Ph Ph Ph A B OH 1. EtMgBr H2CrO4 Zn(Hg), aq. HCI PhCHO ? 2. H₂O, H+ Ph. C D Ph "ར HO OH Earrow_forward
- 7. What is the major organic product obtained from the following reaction sequence? Ph A OH 99 Ph OH D Br HOCH2CH2OH H2SO4 1. Mg, Et₂O 2. PhCH2CHO HCI, H₂O Br OH Ph Ph OH B C Br OH Ph Earrow_forwardPls helparrow_forwardH₂N NH peptide_0e60 A dipeptide is made up of two (2) amino acids. The figure above shows one such dipeptide with an unknown sequence. Your task is to find out the two (2) letter sequence of this dipeptide.arrow_forward
- carbons in each of the structures below. For instance, the central carbon of chloromethylbutane (pictured 3. A chiral carbon is a carbon that is single-bonded to four different types of groups. Identify the chiral above) is a chiral carbon. (Can you see how the groups attached to it are all chemically different?) In each of the chiral molecules below, identify all the carbons that are chiral carbons by drawing a circle around each one of them. (a) the carbohydrate glucose H O (b) the carbohydrate fructose CH₂OH 1C H-C-OH 3 HO-C-H 4 H-C-OH 5 H-C-OH 6CH₂OH D-Glucose (linear form) (c) the amino acid leucine O O H3C. HO H H- -OH CH 3 NH2 H- -OH CH₂OH OHarrow_forwardWe always include controls in the Annexin-V-GFP/Propidium Iodide flow cytometric assay to study apoptosis. List four types of controls in this assay. Why do we need these controls? Explain your answers. After the flow assay, if we like to examine the morphology of the viable, early apoptotic and late apoptotic cells by confocal microscopy, what can we do and what are the expected results?arrow_forward3. (2 points) Your lab partner accidentally used a pen instead of a pencil to mark the baseline and label the lanes of their TLC plate. Briefly (1-2 sentences for each point) describe (a) what would happen to the ink when you develop the TLC plate; and (b) how this would affect the experiment. 1arrow_forward
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