Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Question
Chapter 28, Problem 28.17UKC
Interpretation Introduction
Interpretation:
The step in which the signal gets amplified and the way in which amplification takes place have to be described briefly.
Concept Introduction:
- Hormones: Hormones are chemical messengers which are secreted by the cell in endocrine system and are transported along the blood to stimulate the target cells having the corresponding receptors.
- There are three proteins which are involved in the releasing of a hormone signal. They are receptor, G protein and an enzyme.
- cAMP is a cyclic
nucleotide and it is a second messenger which is synthesized from ATP by the action of the enzyme adenylyl cyclase. Chemically cAMP is a 3’,5’- adenosine monophosphate. - Enzymes are proteins that increase the
rate of reaction by lowering the energy of activation and so they are known as “biological catalysts”. - Secondary messengers are short lived intracellular signaling molecules. Elevated concentration of these types of messengers leads to rapid alteration in the activity of one or more cellular enzymes.
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During a sympathetic nervous system response to an event, your heart rate increases, indicating the part of the heart responsible for controlling heart rate (the sinoatrial node) is innervated by sympathetic nerves. The SA node is also responsive to epinephrine,a hormone secreted by the adrenal medulla. Explain why the onset of the effect of the hormone is so much slower than the onset of the effect from sympathetic nerve stimulation and yet the effect of the hormone lasts much longer than the effect of nerve stimulation.
Feedback loops regulate the release of hormones in either a positive or negative
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loop. Consider this example: The hypothalamus releases thyrotropin-releasing
hormone (TRH), which stimulates the pituitary to release the TSH (thyroid-stimulating hormone).
TSH then stimulates thyroid gland to release thyroid hormone. When elevated levels of thyroid
hormone are detected by the hypothalamus and pituitary further release of TRH and TSH is
suppressed. B. What would happen to the levels of TRH and TSH if a tumor of the thyroid gland
were discovered resulting in uncontrolled release of the thyroid hormone from
the tumor itself?
Place the following steps (showing how a steroid hormone changes the activities of its target cells) in order of what happens first, second, third, fourth, and last. Refer to image.
The hormone-receptor complex enters the nucleus of the cell and binds to the DNA.
The steroid hormone passes through the cell membrane.
The hormone attaches to a receptor in the cytoplasm, forming a hormone-receptor complex.
A gene in the DNA is activated, and transcription and translation take place.
Proteins that alter the cell′s activities, such as enzymes, are made.
2. Place the following steps (showing how a hydrophilic hormone changes the activities of its target cells) in order of what happens first, second, third, and last. Refer to image.
The activity of the target cell is changed by the final enzyme in the cascade.
The second messenger activates or deactivates certain enzymes in a cascade fashion.
A second messenger is activated.
Hormone binds to a receptor protein.
Chapter 28 Solutions
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Ch. 28.1 - While thinking about how a messenger molecule and...Ch. 28.2 - Prob. 28.2PCh. 28.2 - Prob. 28.3PCh. 28.2 - Prob. 28.4PCh. 28.3 - Prob. 28.5PCh. 28.3 - Prob. 28.6KCPCh. 28.4 - Prob. 28.7PCh. 28.4 - Look at the structure of thyroxine shown earlier...Ch. 28.4 - Prob. 28.1CIAPCh. 28.4 - Prob. 28.2CIAP
Ch. 28.4 - Prob. 28.9PCh. 28.5 - Prob. 25.10PCh. 28.6 - Prob. 28.11PCh. 28.6 - Prob. 28.12PCh. 28.6 - Prob. 28.13KCPCh. 28.7 - Identify the functional groups present in THC. Is...Ch. 28.7 - Prob. 28.15KCPCh. 28 - Prob. 28.16UKCCh. 28 - Prob. 28.17UKCCh. 28 - Prob. 28.18UKCCh. 28 - Prob. 28.19UKCCh. 28 - Prob. 28.20UKCCh. 28 - Prob. 28.21UKCCh. 28 - Prob. 28.22APCh. 28 - Prob. 28.23APCh. 28 - Prob. 28.24APCh. 28 - Prob. 28.25APCh. 28 - Prob. 28.26APCh. 28 - Prob. 28.27APCh. 28 - Prob. 28.28APCh. 28 - Prob. 28.29APCh. 28 - Prob. 28.30APCh. 28 - Prob. 28.31APCh. 28 - Prob. 28.32APCh. 28 - Prob. 28.34APCh. 28 - Prob. 28.35APCh. 28 - Prob. 28.36APCh. 28 - Prob. 28.37APCh. 28 - How does epinephrine reach its target tissues?Ch. 28 - Prob. 28.39APCh. 28 - Prob. 28.40APCh. 28 - Prob. 28.41APCh. 28 - Prob. 28.42APCh. 28 - What enzyme catalyzes hydrolysis of the second...Ch. 28 - Prob. 28.44APCh. 28 - Prob. 28.45APCh. 28 - Prob. 28.46APCh. 28 - Prob. 28.47APCh. 28 - Prob. 28.48APCh. 28 - Prob. 28.49APCh. 28 - Prob. 28.50APCh. 28 - Prob. 28.51APCh. 28 - Prob. 28.52APCh. 28 - Prob. 28.53APCh. 28 - Prob. 28.54APCh. 28 - Prob. 28.55APCh. 28 - Prob. 28.56APCh. 28 - Prob. 28.57APCh. 28 - Prob. 28.58APCh. 28 - Prob. 28.59APCh. 28 - Prob. 28.60APCh. 28 - Prob. 28.62APCh. 28 - Prob. 28.63APCh. 28 - Prob. 28.64APCh. 28 - Prob. 28.65APCh. 28 - Prob. 28.66APCh. 28 - Prob. 28.67APCh. 28 - Prob. 28.68APCh. 28 - Prob. 28.69APCh. 28 - Prob. 28.70APCh. 28 - Prob. 28.71APCh. 28 - Prob. 28.72APCh. 28 - Prob. 28.73APCh. 28 - Prob. 28.74APCh. 28 - Prob. 28.75APCh. 28 - Prob. 28.76APCh. 28 - Why do we have brain receptors that respond to...Ch. 28 - Prob. 28.78APCh. 28 - Prob. 28.79APCh. 28 - Prob. 28.80APCh. 28 - Prob. 28.81APCh. 28 - Prob. 28.82APCh. 28 - Prob. 28.83CPCh. 28 - Prob. 28.84CPCh. 28 - Prob. 28.85CPCh. 28 - Prob. 28.86CPCh. 28 - Prob. 28.87CPCh. 28 - Prob. 28.88CPCh. 28 - Prob. 28.89CPCh. 28 - Prob. 28.90CPCh. 28 - Prob. 28.91CPCh. 28 - Prob. 28.92CPCh. 28 - Prob. 28.93CPCh. 28 - Prob. 28.94GPCh. 28 - Prob. 28.95GP
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