Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Chapter 28, Problem 28.74AP
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Interpretation:
The impact and mode of action of cocaine on dopamine level in the brains has to be explained.
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Help me understand how carbon disulfide leads to toxicity in the brain, using terms like distal axonopathy, neurofilaments, covalent cross-linking, adducts, etc.,...please intuitively explain what is happening and where and the effects of it. For example, I know that CS2 reacts with amide and sulfhydryl groups on proteins, but what proteins exactly and where are they located?
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Give standard free energy changes expected for the following reactions:-Succinate -> fumarate (using FAD/FADH2)-Oxaloacetate -> Malate (using NAD/NADH)-NADH --> NAD+ (using FMN/FMNH2)-CoQ --> CoQH2 (using Cytochrome C)
Chapter 28 Solutions
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Ch. 28.1 - While thinking about how a messenger molecule and...Ch. 28.2 - Prob. 28.2PCh. 28.2 - Prob. 28.3PCh. 28.2 - Prob. 28.4PCh. 28.3 - Prob. 28.5PCh. 28.3 - Prob. 28.6KCPCh. 28.4 - Prob. 28.7PCh. 28.4 - Look at the structure of thyroxine shown earlier...Ch. 28.4 - Prob. 28.1CIAPCh. 28.4 - Prob. 28.2CIAP
Ch. 28.4 - Prob. 28.9PCh. 28.5 - Prob. 25.10PCh. 28.6 - Prob. 28.11PCh. 28.6 - Prob. 28.12PCh. 28.6 - Prob. 28.13KCPCh. 28.7 - Identify the functional groups present in THC. Is...Ch. 28.7 - Prob. 28.15KCPCh. 28 - Prob. 28.16UKCCh. 28 - Prob. 28.17UKCCh. 28 - Prob. 28.18UKCCh. 28 - Prob. 28.19UKCCh. 28 - Prob. 28.20UKCCh. 28 - Prob. 28.21UKCCh. 28 - Prob. 28.22APCh. 28 - Prob. 28.23APCh. 28 - Prob. 28.24APCh. 28 - Prob. 28.25APCh. 28 - Prob. 28.26APCh. 28 - Prob. 28.27APCh. 28 - Prob. 28.28APCh. 28 - Prob. 28.29APCh. 28 - Prob. 28.30APCh. 28 - Prob. 28.31APCh. 28 - Prob. 28.32APCh. 28 - Prob. 28.34APCh. 28 - Prob. 28.35APCh. 28 - Prob. 28.36APCh. 28 - Prob. 28.37APCh. 28 - How does epinephrine reach its target tissues?Ch. 28 - Prob. 28.39APCh. 28 - Prob. 28.40APCh. 28 - Prob. 28.41APCh. 28 - Prob. 28.42APCh. 28 - What enzyme catalyzes hydrolysis of the second...Ch. 28 - Prob. 28.44APCh. 28 - Prob. 28.45APCh. 28 - Prob. 28.46APCh. 28 - Prob. 28.47APCh. 28 - Prob. 28.48APCh. 28 - Prob. 28.49APCh. 28 - Prob. 28.50APCh. 28 - Prob. 28.51APCh. 28 - Prob. 28.52APCh. 28 - Prob. 28.53APCh. 28 - Prob. 28.54APCh. 28 - Prob. 28.55APCh. 28 - Prob. 28.56APCh. 28 - Prob. 28.57APCh. 28 - Prob. 28.58APCh. 28 - Prob. 28.59APCh. 28 - Prob. 28.60APCh. 28 - Prob. 28.62APCh. 28 - Prob. 28.63APCh. 28 - Prob. 28.64APCh. 28 - Prob. 28.65APCh. 28 - Prob. 28.66APCh. 28 - Prob. 28.67APCh. 28 - Prob. 28.68APCh. 28 - Prob. 28.69APCh. 28 - Prob. 28.70APCh. 28 - Prob. 28.71APCh. 28 - Prob. 28.72APCh. 28 - Prob. 28.73APCh. 28 - Prob. 28.74APCh. 28 - Prob. 28.75APCh. 28 - Prob. 28.76APCh. 28 - Why do we have brain receptors that respond to...Ch. 28 - Prob. 28.78APCh. 28 - Prob. 28.79APCh. 28 - Prob. 28.80APCh. 28 - Prob. 28.81APCh. 28 - Prob. 28.82APCh. 28 - Prob. 28.83CPCh. 28 - Prob. 28.84CPCh. 28 - Prob. 28.85CPCh. 28 - Prob. 28.86CPCh. 28 - Prob. 28.87CPCh. 28 - Prob. 28.88CPCh. 28 - Prob. 28.89CPCh. 28 - Prob. 28.90CPCh. 28 - Prob. 28.91CPCh. 28 - Prob. 28.92CPCh. 28 - Prob. 28.93CPCh. 28 - Prob. 28.94GPCh. 28 - Prob. 28.95GP
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- Give examples of balanced redox reactions that match the following:-Catabolic-Anabolic-Oxidative-Reductivearrow_forwardIf there are 20uM of a GLUT2 transporter on the surface of a cell, each able to move 8 per second, and 50mM glucose outside of the cell, what is the flux into the cell in mM/sec?arrow_forwardA transporter is responsible for antiporting calcium and glucose. The transporter brings glucose into the cell and sends calcium out of the cell. If blood [calcium] = 2.55mM and intracellular [calcium] = 7uM, blood [glucose] = 5.2mM, and intracellular [glucose] = 40uM, what is the free energy of transport? Assume a membrane potential of 62mV (negative inside).arrow_forward
- An ATP-coupled transporter is used to import 1 phosphate from the extracellular environment. Intracellular phosphate exists at 65mM, while it is 2mM outside.Assume a free energy change of ATP hydrolysis of -42.7 kJ/mol. What is the net free energy change of the coupled reaction? Assume a membrane potential of 70mV.arrow_forwardAnother transporter brings 3 chloride ions into the cell. Outside, chloride has a concentration of 107mM, and 4mM inside the cell. Assuming a membrane potential of 62mV (negative inside), what is the free energy of transport of these ions?arrow_forwardFor the Oxaloacetate -> Malate reaction, assume the normal ratio of NAD/NADH, what is the maximum ratio of Malate/Oxaloacetate that will allow reaction progress?arrow_forward
- A particular particle is trying to cross a membrane by simple diffusion from a high concentration of 20mM to a low concentration of 20uM. If a membrane is 15uM in width, and the diffusion coefficient of the particle is 5 uM/sec, what is the influx in uM/sec?arrow_forwardMechanisms: 1. Give a full arrow-pushing mechanism for the hydrolysis of the gamma phosphate of ATP by an ATPase. 2. Give a full arrow pushing mechanism of the spontaneous redox reaction between NAD+/NADH and oxaloacetate/malate.arrow_forwardDefine the difference between primary and secondary active transport. Is one preferable to another?arrow_forward
- Which B vitamin is responsible for generating the following:- FAD/FMN-NAD/NADH/NADP/NADPH-Coenzyme Aarrow_forwardWhat is the free energy change of an NADH mediated reduction of acetaldehyde to ethanol if blood ethanol is 0.2% by volume, and [Acetaldehyde] = 9uM. Assume the ratio of NAD/NADH is the same as discussed in class.arrow_forwardWhat is the role of each redox cofactor in the cell? Be specific about subcellular localization, etcarrow_forward
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