
(a)
Interpretation:
It should be determined that where is LH produced, and to what class of hormones does it belong.
Concept introduction:
Hormones are chemical substances synthesized in small amounts by endocrine tissues and carried by blood stream to another tissue, where it acts as a messenger to regulate the function of the target tissue or organ.
There are three major classes of molecules which function as hormones in vertebrates and they are,
- Amino acid derivatives: It is a derivative of an amino acid formed by the reaction at the side chain
functional group ,carboxylic acid group, and amino group or by the replacement of a hydrogen atom by heteroatom. - Polypeptides: Polypeptides are organic
polymers having several amino acids attached to each other in a chain. - Steroid: Steroids are a type of organic compound having a molecular structure with four rings connected to each other.
Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are the two hormones involved in fertility which are produced by the pituitary gland.
(a)

Explanation of Solution
LH (luteinizing hormone) is an important hormone involved in fertility which is produced by the pituitary gland. It is a polypeptide hormone.
(b)
Interpretation:
It should be determined that where is progesterone produced, and to what class of hormones does it belong.
Concept introduction:
Hormones are chemical substances synthesized in small amounts by endocrine tissues and carried by blood stream to another tissue, where it acts as a messenger to regulate the function of the target tissue or organ.
There are three major classes of molecules which function as hormones in vertebrates and they are,
- Amino acid derivatives: It is a derivative of an amino acid formed by the reaction at the side chain functional group, carboxylic acid group, and amino group or by the replacement of a hydrogen atom by heteroatom.
- Polypeptides: Polypeptides are organic polymers having several amino acids attached to each other in a chain.
- Steroid: Steroids are a type of organic compound having a molecular structure with four rings connected to each other.
(b)

Explanation of Solution
Progesterone is responsible for the physiological changes in women at specific phases of their life starting in puberty. It is a steroid hormone produced in ovaries.
(c)
Interpretation:
It should be determined that whether the progesterone producing cells have LH receptor on their surface or does LH enters the cells to carry out its function.
Concept introduction:
Hormones are chemical substances synthesized in small amounts by endocrine tissues and carried by blood stream to another tissue, where it acts as a messenger to regulate the function of the target tissue or organ.
There are three major classes of molecules which function as hormones in vertebrates and they are,
- Amino acid derivatives: It is a derivative of an amino acid formed by the reaction at the side chain functional group, carboxylic acid group, and amino group or by the replacement of a hydrogen atom by heteroatom.
- Polypeptides: Polypeptides are organic polymers having several amino acids attached to each other in a chain.
- Steroid: Steroids are a type of organic compound having a molecular structure with four rings connected to each other. They are lipid soluble
Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are the two hormones involved in fertility which are produced by the pituitary gland.
(c)

Explanation of Solution
Progesterone producing cells have LH receptor. LH stimulates both estrogen and progesterone production. Before ovulation LH release is stimulated by estrogen but after ovulation it is inhibited by both estrogen and progesterone.
(d)
Interpretation:
It should be explained that whether the progesterone bind to a cell-surface receptor or does it enter the cell to carry out its function.
Concept introduction:
Hormones are chemical substances synthesized in small amounts by endocrine tissues and carried by blood stream to another tissue, where it acts as a messenger to regulate the function of the target tissue or organ.
There are three major classes of molecules which function as hormones in vertebrates and they are,
- Amino acid derivatives: It is a derivative of an amino acid formed by the reaction at the side chain functional group, carboxylic acid group, and amino group or by the replacement of a hydrogen atom by heteroatom.
- Polypeptides: Polypeptides are organic polymers having several amino acids attached to each other in a chain.
- Steroid: Steroids are a type of organic compound having a molecular structure with four rings connected to each other. This type of hormone is soluble in lipids.
Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are the two hormones involved in fertility which are produced by the pituitary gland.
(d)

Explanation of Solution
Progesterone is responsible for the physiological changes in women at specific phases of their life starting in puberty. It is a steroid hormone produced in ovaries. Steroid hormones are lipid soluble and so it can enter cells.
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Chapter 28 Solutions
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- The reduced coenzymes generated by the citric acid cycle donate electrons in a series of reactions called the electron-transport chain. The energy from the electron-transport chain is used for oxidative phosphorylation. Which compounds donate electrons to the electron- transport chain? H₂O NADH பப NAD+ ATP ADP FADH₂ FAD Which compounds are the final products of the electron-transport chain and oxidative phosphorylation? H₂O NADH NAD+ ΠΑΤΡ Π ADP FADH₂ FAD Which compound is the final electron acceptor in the electron-transport chain? Оно NADH NAD+ ATP ADP FADH₂ FADarrow_forwardHexokinase in red blood cells has a Michaelis constant (KM) of approximately 50 μM. Because life is hard enough as it is, let's assume that hexokinase displays Michaelis-Menten kinetics. What concentration of blood glucose yields an initial velocity (V) equal to 90% of the maximal velocity (Vmax)? [glucose] = What does the calculated substrate concentration at 90% Vmax tell you if normal blood glucose levels range between approximately 3.6 and 6.1 mM? Hexokinase operates near Vmax only when glucose levels are low. Hexokinase normally operates far below Vmax. Hexokinase operates near Vmax only when glucose levels are high. Hexokinase normally operates near Vmax mMarrow_forwardClassify each coenzyme or distinguishing characteristic based on whether it corresponds to catalytic or stoichiometric coenzymes. Catalytic coenzymes Answer Bank Stoichiometric coenzymes lipoic acid FAD used once coenzyme A regenerated thiamine pyrophosphate (TPP) NAD+arrow_forward
- The oxidation of malate by NAD+ to form oxaloacetate is a highly endergonic reaction under standard conditions. AG +29 kJ mol¹ (+7 kcal mol-¹) Malate + NAD+ oxaloacetate + NADH + H+ The reaction proceeds readily under physiological conditions. = Why does the reaction proceed readily as written under physiological conditions? The NADH produced during glycolysis drives the reaction in the direction of malate oxidation. The steady-state concentrations of the products are low compared with those of the substrates. The reaction is pushed forward by the energetically favorable oxidation of fumarate to malate. Endergonic reactions such as this occur spontaneously without the input of free energy. Assuming an [NAD+ ]/[NADH] ratio of 8, a temperature of 25°C, and a pH of 7, what is the lowest [malate]/[oxaloacetate] ratio at which oxaloacetate can be formed from malate? [malate] [oxaloacetate]arrow_forwardCalculate and compare the AG values for the oxidation of succinate by NAD+ and FAD. Use the data given in the table to find the E of the NAD+: NADH and fumarate:succinate couples, and assume that E for the enzyme-bound FAD: FADH2 redox couple is nearly +0.05 V. Oxidant Reductant " E' (V) NAD+ NADH + H+ 2 -0.32 Fumarate Succinate AG°' for the oxidation of succinate by NAD+: AG°' for the oxidation of succinate by FAD: 2 -0.03 Why is FAD rather than NAD+ the electron acceptor in the reaction catalyzed by succinate dehydrogenase? The electron-transport chain can regenerate FAD, but not NAD+. FAD is an oxidant, whereas NAD+ is a reductant. The oxidation of succinate requires two NAD+ molecules but only one FAD molecule. The oxidation of succinate by NAD+ is not thermodynamically feasible. kJ mol-1 kJ mol-1arrow_forwardUse the cellular respiration interactive to help you complete the passage. 2,4-dinitrophenol (DNP) was a popular ingredient in diet pills in the 1930s before it was discovered that moderate doses of the compound cause exceptionally high body temperature and even death. Complete the passage detailing how DNP's mechanism of action explains why it causes both high body temperature and weight loss. 2,4-dinitrophenol (DNP) causes of returning to the mitochondrial matrix through to pass directly across the inner mitochondrial membrane instead proteins. Because of DNP's effect on the mitochondrion, less energy is captured in the form of energy is instead wasted as heat. and more protons electrons ATP NADH sugars cytochrome ATP synthase heatarrow_forward
- To answer this question, you may reference the Metabolic Map. Select the reactions of glycolysis in which ATP is produced. 1,3-Bisphosphoglycerate 3-phosphoglycerate Glyceraldehyde 3-phosphate 1,3-bisphosphoglycerate Fructose 6-phosphate fructose 1,6-bisphosphate Phosphoenolpyruvate pyruvate Glucose glucose 6-phosphate Suppose 17 glucose molecules enter glycolysis. Calculate the total number of inorganic phosphate (P) molecules required as well as the total number of pyruvate molecules produced. P required: pyruvate produced: molecules moleculesarrow_forwardSuppose a marathon runner depletes carbohydrate stores after a four-hour run. The runner's nutritionist suggests replenishing carbohydrate stores by eating carbohydrates. However, the runner is also concerned about weight loss and wants to know if fats can be directly converted into carbohydrates. How should the nutritionist respond to the runner? Yes, the glyoxylate cycle can be used to convert acetyl CoA into succinate, which can then be converted into carbohydrates. No, the two decarboxylation reactions of the citric acid cycle preclude the net conversion of acetyl CoA into carbohydrates. No, the citric acid cycle converts acetyl CoA into oxaloacetate, but there is no pathway to form glucose from oxaloacetate. Yes, pyruvate carboxylase can convert acetyl CoA into pyruvate, which can be used to form glucose through gluconeogenesis.arrow_forwardThe crossover technique can reveal the precise site of action of a respiratory-chain inhibitor. Britton Chance devised elegant spectroscopic methods for determining the proportions of the oxidized and reduced form of each carrier. This determination is feasible because the forms have distinctive absorption spectra, as illustrated in the graph for cytochrome c. Upon the addition of a new inhibitor to respiring mitochondria, the carriers between NADH and ubiquinol (QH2) become more reduced, and those between cytochrome c and O₂ become more oxidized. Where does your inhibitor act? Complex I Complex II Complex III Complex IV Absorbance coefficient (M-1 cm x 10-5) 10 1.0 0.5 400 Reduced Oxidized 500 Wavelength (nm) 600arrow_forward
- Why are the electrons carried by FADH2 not as energy rich as those carried by NADH? FADH2 carries fewer high-energy electrons than NADH. OFADH2 is less negatively charged than NADH. OFADH2 has a lower phosphoryl-transfer potential than NADH. FADH₂ has a lower reduction potential than NADH. What is the consequence of this difference? Electrons flow from NADH to FADH2 before they are transferred to O₂. Electron flow FADH₂ to O, results in the production of more ATP than does electron flow from NADH. Electron flow from FADH₂ to O, pumps fewer protons than does electron flow from NADH. Electron flow from FADH, to O, consumes more free energy than does electron flow from NADH. A simple equation relates the standard free-energy change, AG", to the change in reduction potential, AE. AG=-FAE Then represents the number of transferred electrons, and F is the Faraday constant with a value of 96.48 kJ mol¹ V-¹. Use the standard reduction potentials provided to determine the standard free energy…arrow_forwardMatch each enzyme with its description. catalyzes the formation of isocitrate synthesizes succinyl CoA generates malate generates ATP converts pyruvate into acetyl CoA converts pyruvate into oxaloacetate condenses oxaloacetate and acetyl CoA catalyzes the formation of oxaloacetate synthesizes fumarate catalyzes the formation of a-ketoglutarate Answer Bank succinate dehydrogenase a-ketoglutarate dehydrogenase aconitase fumarase citrate synthase malate dehydrogenase pyruvate carboxylase pyruvate dehydrogenase complex isocitrate dehydrogenase succinyl CoA synthetasearrow_forwardcoo ☐ CH2 coo Malonate Determine how the concentration of each citric acid cycle intermediate will change immediately after the addition of malonate. The concentration of citrate will The concentration of isocitrate will The concentration of α-ketoglutarate will The concentration of succinyl CoA will The concentration of succinate will The concentration of fumarate will The concentration of malate will The concentration of oxaloacetate will Why is malonate not a substrate for succinate dehydrogenase? Malonate lacks a thioester bond that has high transfer potential. Malonate has two carboxylic acid groups. Malonate is not large enough to bind to the enzyme. Malonate only has one methylene group.arrow_forward
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