Concept explainers
(a)
Interpretation:
The number of molecules of acetyl-CoA that are produced by the catabolism of myristic acid should be determined.
Concept introduction:
Fatty acids are aliphatic mono-
Fatty acids in the body are mostly oxidized by
(b)
Interpretation:
The number of molecules of acetyl-CoA that are produced by the catabolism of caprylic acid should be determined.
Concept introduction:
Fatty acids are aliphatic mono-carboxylic acids that are mostly obtained from the hydrolysis of natural fats and oils. They have a general formula
Fatty acids in the body are mostly oxidized by
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FUND.OF GEN CHEM CHAP 1-13 W/ACCESS
- (8) B-ketothiolase is a multifunctional enzyme in lipid catabolism. Which of the following is NOT one of its functions? (A) It catalyzes the release of (2) acetyl CoA from acetoacetyl CoA during ketolysis. (B) It removes an acetyl CoA from the fatty acyl chain during B-oxidation. (C) It forms acetoacetate by removing acetyl CoA from HMG CoA during ketogenesis. (D) It condenses (2) acetyl CoA molecules to form acetoacetyl CoA during ketogenesis. (9) What is HMG-COA, in the context of fatty acid catabolism? (A) a product of fatty acid oxidation (B) a ketone body made in liver cells (C) a 6-carbon precursor to the acetoacetate ketone body (D) a 4-carbon precursor to the acetoacetate ketone body (E) a product formed when the B-hydroxybutyrate ketone body is oxidized in brain cells (10) Which of the following symptoms might you expect to see in a patient with defective acyl CoA dehydrogenase under fasting conditions? (A) slowed gluconeogenesis in liver (B) hypoglycemia (C) elevated glycogen…arrow_forwardConsider the fatty acids: (a) Arachidic acid (C20H40O2); molar mass = 312.5 g/mol) (b) Palmitoleic acid(C16H30O2); molar mass = 256.4 g/mol). i. How many cycles of β -oxidation are needed for complete oxidation?ii. How many molecules of acetyl CoA are formed from its complete catabolism?iii. Calculate the number of molecules (moles) of ATP formed (net) by the completecatabolism of each fatty acid (show your calculation).iv. Calculate number of moles of ATP formed per gram of each fatty acid metabolized.arrow_forwardGiven the following statements, identify which are true and which are not. (1) Two ribose subunits are present in the coenzyme flavin adenine dinucleotide. (2) In the common metabolic pathway, 10 molecules of ATP are produced per acetyl CoA catabolized. (3) The purpose of step 2 in the CAC is to convert a secondary alcohol to a tertiary alcohol.arrow_forward
- How many molecules of acetyl CoA, FADH2, and NADH are produced in the catabolism of a molecule of arachidonic acid, an 20-carbon carboxylic acid? How many times does the spiral reaction sequence occurarrow_forwardFor myristic acid, C 13H 27CO 2H: (a) How many molecules of acetyl CoA are formed from complete β-oxidation? (b) How many cycles of β-oxidation are needed for complete oxidation?arrow_forwardIn the presence of an excess of [14C]acetyl- COA, the metabolic pool of malonyl-CoA becomes labeled at which carbon atom(s)?arrow_forward
- How many acetyl CoA molecules are produced in one cycle of beta oxidation? How many cycles would it take to catabolize a stearic acid molecule (a fatty acid, [18:0]) into acetyl Co A units? a)How many acetyl CoA molecules would be produced? b) How many reduced nucleotides would be produced? c) If a molecule of glucose produces a net 32 ATP when completely catabolized, which do you think will produce more energy, one molecule of glucose or one molecule of stearic acid? Justify your answer.arrow_forwardUnder conditions where ketone bodies are being produced in the liver, how many ATPs can be produced from a molecule of palmitic acid if all resulting molecules of acetyl-CoA are converted into β-hydroxybutyrate?arrow_forwardFatty acids are converted to their coenzyme A esters in a reversible reaction catalyzed by acyl-CoA synthetase: R-COO +ATP +COA R-C-COA +AMP + PPi a) The reaction involves two steps the first of which forms an enzyme-bound intermediate identified as the mixed anhydride of the fatty acid and AMP: R-C-O-P-O-nibose-adenine Write two chemical equations coresponding to the two steps of the reaction catalyzed by the synthetase. b) The acyl-CoA synthetase reaction as written above is readily reversible. How might the reaction be made to favor formation of fatty acyl-CoA? Write within the box. Anything outside the box will not be graded. From thearrow_forward
- D) Carbohydrate catabolism involves substrate-level phosphorylation. E) My answer is not here 27. The adduct acetoacetyl-acyl carrier protein is formed as an intermediate during fatty acid biosynthesis. The CO2 used to synthesize malonyl-S-CoA is lost. Would this help make the reaction more or less energetically favorable? A) Loss of CO2 increases entropy (AS) and therefore decreases the favorability of the reaction (AG). B) Loss of CO2 has no effect on entropy (AS) and therefore does not affect the favorability of the reaction (AG). C) Loss of CO2 increases entropy (AS) and therefore increases the favorability of the reaction (AG). D) Loss of CO2 decreases entropy (AS) and therefore decreases the favorability of the reaction (AG). E) Loss of CO2 decreases entropy (AS) and therefore increases the favorability of the reaction (AG).arrow_forwardBehenate (C22H44O2) can be obtained by chain elongation from palmitate. How many ATP equivalents are produced in the degradation of behenate to eleven acetyl-CoA?arrow_forwardA biological Claisen reaction occurs in the conversion of two acetyl CoA molecules to one acetoacetyl CoA. Analyze each step of the incomplete mechanism and add the missing curved arrows. The base is abbreviated as B: in the mechanism.arrow_forward
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