Concept explainers
Interpretation:
The transformation which is necessary to convert
Concept introduction:
Glycolysis: This is the
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FUND.OF GEN CHEM CHAP 1-13 W/ACCESS
- During gluconeogenesis, the three irreversible steps of glycolysis have to be bypassed. The first step is the conversion of pyruvate to phosphoenolpyruvate. Which of the following statement is false regarding the reaction step? Select one: a. Conversion of oxaloacetate from pyruvate occurs in mitochondria and shuttled into the cytosol. b. Formation of phosphoenolpyruvate requires both ATP and GTP as an energy source. c. Acetyl CoA is an activator of enzyme pyruvate carboxylase. d. This reaction involves two-step process catalyzed by pyruvate carboxylase and phosphoenolpyruvate carboxykinasearrow_forwardIn glycolysis, the conversion of phosphoenolpyruvate (PEP) to pyruvate is considered irreversible. Yet, in gluconeogenesis, this "irreverisble" reaction is bypassed and pyruvate is eventually converted to PEP. Explain how gluconeogenesis bypasses this irreverisble reaction. Include the enzymes required to convert pyruvate to PEP + the intermediate that is created. Imagine a scenario where the PDH complex has picked up an "activating" mutation causing it to convert pyruvate into acetyl CoA in an unregulated manner.There is way too much acetyl CoA than is actually necessary. Explain in a sentence or two how the body would compensate for thisarrow_forwardThe last step of glycolysis converts phosphoenolpyruvate to pyruvate. Several intermediates involved in the steps for the conversion of pyruvate to phosphoenolpyruvate via gluconeogenesis are given. Choose and place the right intermediates produced from these steps in the correct order. (Select from: Oxaloacetate, Ethanol, Pyruvate, Ketoglutarate, Phosphoenolpyruvate, Malate, Fumarate) _________ → _________ → _________ → __________ → Phosphoenolpyruvatearrow_forward
- In the first stage of glycolysis, fructose-1,6-bisphosphate iscleaved to form glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. The latter molecule can then be converted to glyceraldehyde-3-phosphate. Illustrate themechanisms whereby these reactions occurarrow_forwardConsider an alternative glycolysis pathway that starts with the phosphorylation of glucose to give glucose-6-phosphate. This (hypothetical) pathway exists in a (hypothetical) organism that does not express glucose-6-phosphate isomerase. Instead, the next step of this hypothetical pathway is a Glucose-6-Phosphate Aldolase. Draw the product or products that would be obtain by the reaction of Glucose – 6 – Phosphate with Glucose – 6 Phosphate Aldolase. Assume the reaction is completely irreversible. Explain in 1-3 sentences how you obtained your answerarrow_forwardIf the conversion of glycerol to glyceraldehyde 3-phosphate releases 1 molecule of ATP, how many molecules of ATP are released during the conversion of glycerol to pyruvate?arrow_forward
- Why is the isomerization of glucose-6-phosphate (G6P) to fructose-6-phosphate (F6P) an important step in glycolysis? How is the isomerization of F6P back into G6P prevented?arrow_forwardThe conversion of 1 mol of fructose 1,6-bisphosphate to 2 mol of pyruvate by the glycolytic pathway results in what type of net formation?arrow_forwardIn glycolysis, the conversion of phosphoenolpyruvate (PEP) to pyruvate is considered irreversible. Yet, in gluconeogenesis, this "irreverisble" reaction is bypassed and pyruvate is eventually converted to PEP. Explain how gluconeogenesis bypasses this irreverisble reaction. For full credit, detail: 1) The enzymes required to convert pyruvate to PEP 2) The intermediate that is created 3) The "energetic cost" of the reaction(s) (For instance, is the hydrolysis of a high-energy bond in a nucleotide triphosphate necessary?)arrow_forward
- Fourteen NADPH molecules are required to produce one molecules of palmitic acid from acetyl CoA. Substantiate this statement by referring to the enzymatic activities involved in reduction steps during fatty acid synthesis and the number of cycles required to produce palmitic acid from acetyl CoA. How many molecules of ATP is required for the synthesis of palmitic acid from cytosolic acetyl-CoA?arrow_forwardWhat is the advantage for some tumors to stop expressing the genes for glucose-6-phosphatase, phosphoenolpyruvate carboxykinase, and fructose bisphosphatase?arrow_forwardOxaloacetate can be directly converted to [PEP/glucose/citrate/malate] in the process of gluconeogenesis. Oxaloacetate can be directly converted to [PEP/glucose/citrate/ malate] upon condensation with acetyl-CoA. Oxaloacetate can be directly converted to [PEP/glucose/citrate/malate] by a reversible enzyme in the citric acid cycle. Oxaloacetate, via many enzymes, is an important source of [PEP/glucose/citrate/malate] in the liver for tissues that rely on carbohydrates for the fuel source. help fill in the blanksarrow_forward
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