The given compound that can’t be prepared from an alkyl halide or carboxylic acid which serves as a precursor in the preparation of the given amine has to be explained. Concept Introduction : When sodium cyanide is allowed to react with alkyl halide, halide group is replaced by cyanide group via S N 2 nucleophilic substitution reaction. The cyanide group on treatment with lithium aluminum hydride which is a strong reducing agent followed by water work-up, it reduces the cyanide group into methylene primary amine. There is a single carbon skeleton increment in the given compound through this process. The carboxylic acid is converted into the corresponding chloride using thionyl chloride which is allowed to react with ammonia giving the corresponding amide. The amide group on treatment with lithium aluminum hydride which is a strong reducing agent followed by water work-up, it reduces the amide group into methylene primary amine. To find: Explain the reason for the given compound that can’t be prepared from an alkyl halide or carboxylic acid which serves as a precursor in the preparation of the given amine Give the general reaction for amine preparation from alkyl halide or carboxylic acid

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Answer 1

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Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 23.4, Problem 11CC

Interpretation Introduction

Interpretation: The given compound that can’t be prepared from an alkyl halide or carboxylic acid which serves as a precursor in the preparation of the given amine has to be explained.

Concept Introduction:

When sodium cyanide is allowed to react with alkyl halide, halide group is replaced by cyanide group via S_N2 nucleophilic substitution reaction. The cyanide group on treatment with lithium aluminum hydride which is a strong reducing agent followed by water work-up, it reduces the cyanide group into methylene primary amine. There is a single carbon skeleton increment in the given compound through this process.

The carboxylic acid is converted into the corresponding chloride using thionyl chloride which is allowed to react with ammonia giving the corresponding amide. The amide group on treatment with lithium aluminum hydride which is a strong reducing agent followed by water work-up, it reduces the amide group into methylene primary amine.

To find: Explain the reason for the given compound that can’t be prepared from an alkyl halide or carboxylic acid which serves as a precursor in the preparation of the given amine

Give the general reaction for amine preparation from alkyl halide or carboxylic acid

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Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 23.4, Problem 11CC

Interpretation Introduction

Interpretation: The given compound that can’t be prepared from an alkyl halide or carboxylic acid which serves as a precursor in the preparation of the given amine has to be explained.

Concept Introduction:

When sodium cyanide is allowed to react with alkyl halide, halide group is replaced by cyanide group via S_N2 nucleophilic substitution reaction. The cyanide group on treatment with lithium aluminum hydride which is a strong reducing agent followed by water work-up, it reduces the cyanide group into methylene primary amine. There is a single carbon skeleton increment in the given compound through this process.

The carboxylic acid is converted into the corresponding chloride using thionyl chloride which is allowed to react with ammonia giving the corresponding amide. The amide group on treatment with lithium aluminum hydride which is a strong reducing agent followed by water work-up, it reduces the amide group into methylene primary amine.

To find: Explain the reason for the given compound that can’t be prepared from an alkyl halide or carboxylic acid which serves as a precursor in the preparation of the given amine

Give the general reaction for amine preparation from alkyl halide or carboxylic acid

Expert Solution & Answer

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Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 23.4, Problem 11CC

Interpretation Introduction

Interpretation: The given compound that can’t be prepared from an alkyl halide or carboxylic acid which serves as a precursor in the preparation of the given amine has to be explained.

Concept Introduction:

When sodium cyanide is allowed to react with alkyl halide, halide group is replaced by cyanide group via S_N2 nucleophilic substitution reaction. The cyanide group on treatment with lithium aluminum hydride which is a strong reducing agent followed by water work-up, it reduces the cyanide group into methylene primary amine. There is a single carbon skeleton increment in the given compound through this process.

The carboxylic acid is converted into the corresponding chloride using thionyl chloride which is allowed to react with ammonia giving the corresponding amide. The amide group on treatment with lithium aluminum hydride which is a strong reducing agent followed by water work-up, it reduces the amide group into methylene primary amine.

To find: Explain the reason for the given compound that can’t be prepared from an alkyl halide or carboxylic acid which serves as a precursor in the preparation of the given amine

Give the general reaction for amine preparation from alkyl halide or carboxylic acid

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 23.4, Problem 11CC

Interpretation Introduction