Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 2, Problem 22P

Consider a protein in which a negatively charged glutamic acid side chain (pks = 4.2) makes a salt bridge (ion—ion interaction) with a positively charged histidine side chain (pKa = 6.5).
a. Do you predict that this salt bridge will become stronger, become weaker, or be unaffected as pH increases from pH = 7.0 to pH = 7.5?
b. Justify your answer with calculations of partial charges on these amino acid side chains. (Hint Consider lessons from Coulomb's law, and the Henderson-Hasselbalch equation)

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Draw the chemical structure of the tripeptide, HEL (L - amino acids), at pH = 7.0. Calculate isoelectric point
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Biomolecules - Protein - Amino acids; Author: Tutorials Point (India) Ltd.;https://www.youtube.com/watch?v=ySNVPDHJ0ek;License: Standard YouTube License, CC-BY