Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Chapter 12.8, Problem 12.1MRP
Interpretation Introduction
Interpretation:
The mechanism of the given reaction has to be explained using curved arrow formalism.
Concept Introduction:
Curved Arrow formalism: The tail of the arrow is placed on the electrons that move. Electrons never flow from atoms which are electron-poor to atoms which are electron-rich, so a curved arrow will never point from an atom with a positive charge to an atom with a negative charge.
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To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser.
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of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help
To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine.
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Chapter 12 Solutions
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Ch. 12.2 - Locate and identify the functional groups in (a)...Ch. 12.2 - Draw structures for molecules that fit the...Ch. 12.3 - Prob. 12.3PCh. 12.3 - There are two branched-chain isomers with the...Ch. 12.4 - Draw the following three isomers of C5H12 as...Ch. 12.4 - Prob. 12.6PCh. 12.4 - Prob. 12.7PCh. 12.4 - Draw both condensed and line structures for the...Ch. 12.5 - Which of the following structures represent the...Ch. 12.5 - Are the pairs of compounds shown below the same...
Ch. 12.6 - Identify each carbon in the molecule shown in...Ch. 12.6 - Prob. 12.12PCh. 12.6 - Prob. 12.13PCh. 12.6 - Draw and name alkanes that meet the following...Ch. 12.6 - Prob. 12.15KCPCh. 12.6 - Prob. 12.1CIAPCh. 12.6 - Prob. 12.2CIAPCh. 12.6 - Prob. 12.3CIAPCh. 12.8 - Prob. 12.1MRPCh. 12.8 - Prob. 12.2MRPCh. 12.8 - Prob. 12.16PCh. 12.8 - Write the structures of all singly chlorinated...Ch. 12.10 - Prob. 12.18PCh. 12.10 - Prob. 12.19PCh. 12.10 - What is wrong with the following names? It will be...Ch. 12.10 - Prob. 12.21KCPCh. 12.10 - Prob. 12.4CIAPCh. 12.10 - (a) What common produce items might you see...Ch. 12 - Convert the following models into line drawings...Ch. 12 - Prob. 12.23UKCCh. 12 - Prob. 12.24UKCCh. 12 - Give the IUPAC names for the following...Ch. 12 - Prob. 12.26UKCCh. 12 - What characteristics of carbon make possible the...Ch. 12 - Prob. 12.28APCh. 12 - Prob. 12.29APCh. 12 - Prob. 12.30APCh. 12 - For each of the following, give an example of a...Ch. 12 - Identify the highlighted functional groups in the...Ch. 12 - Identify the functional groups in the following...Ch. 12 - Propose structures for molecules that fit the...Ch. 12 - Prob. 12.35APCh. 12 - What requirement must be met for two compounds to...Ch. 12 - Prob. 12.37APCh. 12 - Prob. 12.38APCh. 12 - Prob. 12.39APCh. 12 - Prob. 12.40APCh. 12 - Give an example of a compound that meets the...Ch. 12 - (a)There are two isomers with the formula C4H10....Ch. 12 - Write condensed structures for the following...Ch. 12 - Prob. 12.44APCh. 12 - Prob. 12.45APCh. 12 - Which of the following pairs of structures are...Ch. 12 - Prob. 12.47APCh. 12 - Prob. 12.48APCh. 12 - Prob. 12.49APCh. 12 - What are the IUPAC names of the following alkanes?Ch. 12 - Prob. 12.51APCh. 12 - Write condensed structures for the following...Ch. 12 - Draw line structures for the following...Ch. 12 - Name the following cycloalkanes:Ch. 12 - Prob. 12.55APCh. 12 - Prob. 12.56APCh. 12 - Prob. 12.57APCh. 12 - Prob. 12.58APCh. 12 - Prob. 12.59APCh. 12 - Prob. 12.60APCh. 12 - Prob. 12.61APCh. 12 - Write the formulas of the four singly chlorinated...Ch. 12 - Write the formulas of the three doubly brominated...Ch. 12 - Identify the indicated functional groups in the...Ch. 12 - The line structure for pregabalin (Lyrica) is...Ch. 12 - Prob. 12.66CPCh. 12 - Prob. 12.67CPCh. 12 - Most lipsticks are about 70% castor oil and wax....Ch. 12 - Prob. 12.69CPCh. 12 - Prob. 12.70CPCh. 12 - Prob. 12.71CPCh. 12 - Which of the following structures represent the...
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- To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!arrow_forwardWhich type of enzyme catalyses the following reaction? oxidoreductase, transferase, hydrolase, lyase, isomerase, or ligase.arrow_forward+NH+ CO₂ +P H₂N + ATP H₂N NH₂ +ADParrow_forward
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