The way in which regulatory enzymes can be influenced by reversible covalent modification. Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

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Answer 1

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Chapter 10.7, Problem 4RIA

Summary Introduction

To determine: The way in which regulatory enzymes can be influenced by reversible covalent modification.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Summary Introduction

To determine: The group that is used for reversible covalent modification with glutamine synthetase and the form of the active enzyme.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

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a) Based on the mechanism shown in Figure 2A, what type of enzyme is transpeptidase? : Lyase Isomerase Ligase Hydrolase Oxidoreductase Transferase b) Transpeptidases have two substrates. From Figure 2A, what type of mechanism do they most likely adopt in processing the two substrates? sequential or ping-pong c) β-lactams inactivate transpeptidases by forming a covalent bond with the serine residue in the active site. Based on this description and Figure 2B caption, what type of inhibitor are β-lactams? _________________________________________ d) Based on the mechanism for lactamase shown in Figure 3, what type of enzyme is lactamase? Lyase Isomerase Ligase Hydrolase Oxidoreductase Transferase e) Based on your answer in d, what other reactant, in addition to the antibiotic substrate, needs to be in the active site of lactamase for the hydrolysis reaction to proceed? ____________________

Answer 2

Question

Chapter 10.7, Problem 4RIA

Summary Introduction

To determine: The way in which regulatory enzymes can be influenced by reversible covalent modification.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Summary Introduction

To determine: The group that is used for reversible covalent modification with glutamine synthetase and the form of the active enzyme.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

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Answer 3

Question

Chapter 10.7, Problem 4RIA

Summary Introduction

To determine: The way in which regulatory enzymes can be influenced by reversible covalent modification.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Summary Introduction

To determine: The group that is used for reversible covalent modification with glutamine synthetase and the form of the active enzyme.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

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Answer 4

Question

Chapter 10.7, Problem 4RIA

Summary Introduction

To determine: The way in which regulatory enzymes can be influenced by reversible covalent modification.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Summary Introduction

To determine: The group that is used for reversible covalent modification with glutamine synthetase and the form of the active enzyme.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

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Answer 5

Chapter 10.7, Problem 4RIA

Summary Introduction

To determine: The way in which regulatory enzymes can be influenced by reversible covalent modification.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Summary Introduction

To determine: The group that is used for reversible covalent modification with glutamine synthetase and the form of the active enzyme.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Answer 6

Chapter 10.7, Problem 4RIA

Summary Introduction

To determine: The way in which regulatory enzymes can be influenced by reversible covalent modification.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Answer 7

Chapter 10.7, Problem 4RIA

Summary Introduction

To determine: The way in which regulatory enzymes can be influenced by reversible covalent modification.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Answer 8

Summary Introduction

To determine: The group that is used for reversible covalent modification with glutamine synthetase and the form of the active enzyme.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Answer 9

Summary Introduction

To determine: The group that is used for reversible covalent modification with glutamine synthetase and the form of the active enzyme.

Introduction: The metabolic pathway can be altered by the direct inhibition or stimulation of the “critical enzyme” activities. Such regulation is posttranslational regulation because it occurs after the synthesis of the enzyme. Covalent modification, cleavage of the protein, and allosteric regulation are some mechanisms of posttranslational regulation.

Answer 10

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Answer 12

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Answer 13

Ch. 10.1 - Figure 10.2 The Relationship of G to the...Ch. 10.1 - What kinds of work are carried out in a cell?...Ch. 10.1 - What is thermodynamics? Summarize the first and...Ch. 10.1 - Define entropy and enthalpy. Do living cells...Ch. 10.1 - Prob. 4RIA Ch. 10.1 - Prob. 5RIA Ch. 10.2 - Why is ATP called a high-energy molecule? How is...Ch. 10.2 - Describe the energy cycle and ATPs role in it....Ch. 10.3 - Prob. 1MI Ch. 10.3 - Prob. 2MI

Solution Summary: The author explains that the metabolic pathway can be altered by the direct inhibition or stimulation of the "critical enzyme" activities.

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