Which of the following statements regarding signaling in normal cells and cancer cells is false? a. In normal cells, RTK transphosphorylation is strictly dependent on ligand binding. Ligand binding promotes a conformational change in the RTKS that is required for dimerization, and dimerization is required for transphosphorylation. b. Cancers cells that over-express RTK's can respond to tiny amounts of ligand, and in some instances signaling can be ligand-independent. c. Cancer cells that have established several autocrine signaling loops have a poor prognosis, because these cells have enabled multiple independent mitogenic signal transduction pathways. 4 d. The extracellular ectodomains of all RTKs are highly conserved in primary sequence and structure. e RTKs have a hydrophilic extracellular ectodomain, and hydrophobic transmembrane domain, and a hydrophilic cytoplasmic domain, which contains the catalytic portion of the protein.

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Which of the following statements regarding signaling in normal cells and cancer cells is false?
a. In normal cells, RTK transphosphorylation is strictly dependent on ligand binding. Ligand binding promotes a
conformational change in the RTKS that is required for dimerization, and dimerization is required for
transphosphorylation.
b. Cancers cells that over-express RTK's can respond to tiny amounts of ligand, and in some instances signaling
can be ligand-independent.
c. Cancer cells that have established several autocrine signaling loops have a poor prognosis, because these
cells have enabled multiple independent mitogenic signal transduction pathways.
4
d. The extracellular ectodomains of all RTKS are highly conserved in primary sequence and structure.
e. RTKS have a hydrophilic extracellular ectodomain, and hydrophobic transmembrane domain, and a
hydrophilic cytoplasmic domain, which contains the catalytic portion of the protein.
Transcribed Image Text:Which of the following statements regarding signaling in normal cells and cancer cells is false? a. In normal cells, RTK transphosphorylation is strictly dependent on ligand binding. Ligand binding promotes a conformational change in the RTKS that is required for dimerization, and dimerization is required for transphosphorylation. b. Cancers cells that over-express RTK's can respond to tiny amounts of ligand, and in some instances signaling can be ligand-independent. c. Cancer cells that have established several autocrine signaling loops have a poor prognosis, because these cells have enabled multiple independent mitogenic signal transduction pathways. 4 d. The extracellular ectodomains of all RTKS are highly conserved in primary sequence and structure. e. RTKS have a hydrophilic extracellular ectodomain, and hydrophobic transmembrane domain, and a hydrophilic cytoplasmic domain, which contains the catalytic portion of the protein.
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