The figure below shows a signaling pathway activated by the binding of ådrenáline to the beta-adrenergic receptor. Binding of adrenaline to the receptor causes GTP-binding and activation of G proteins. Active GTP-boundG protein activates adenylate cyclase to initiate a signaling cascade that affects cellular responses, and includes cellular changes to mediate increased heart rate and accounts for the flight-or-fight response. activated adrenaline activated B-adrenergic receptor adenylate cyclase G protein subunit adenylate cyclase 2/ 3. GTP GDP conformational ATP CAMP change in receptor heterotrimeric G protein ACAMP inactive protein kinase A active protein kinase A cellular responses Consider the homozygous mutation in which a cell produces a variant of the adrenergic receptor that is constitutively active in the absence of ligand. Which of the following are true in this cell? Select all that apply. Protein Kinase A is always activated CAMP concentration is higher than normal Heart rate decreases Heart rate increases

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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The figure below shows a signaling pathway activated by the binding of adrenaline to
the beta-adrenergic receptor.
Binding of adrenaline to the receptor causes GTP-binding and activation of G
proteins. Active GTP-boundG protein activates adenylate cyclase to initiate a
signaling cascade that affects cellular responses, and includes cellular changes to
mediate increased heart rate and accounts for the flight-or-fight response.
activated
adrenaline
activated
B-adrenergic receptor adenylate
cyclase
adenylate
cyclase
G protein
subunit
GTP
3.
GDP
conformational
ATP
CAMP
change in receptor
heterotrimeric G protein
ACAMP
inactive
protein kinase A
active
protein kinase A
cellular responses
Consider the homozygous mutation in which a cell produces a variant of the
adrenergic receptor that is constitutively active in the absence of ligand.
Which of the following are true in this cell? Select all that apply.
Protein Kinase A is always activated
CAMP concentration is higher than normal
Heart rate decreases
Heart rate increases
Transcribed Image Text:The figure below shows a signaling pathway activated by the binding of adrenaline to the beta-adrenergic receptor. Binding of adrenaline to the receptor causes GTP-binding and activation of G proteins. Active GTP-boundG protein activates adenylate cyclase to initiate a signaling cascade that affects cellular responses, and includes cellular changes to mediate increased heart rate and accounts for the flight-or-fight response. activated adrenaline activated B-adrenergic receptor adenylate cyclase adenylate cyclase G protein subunit GTP 3. GDP conformational ATP CAMP change in receptor heterotrimeric G protein ACAMP inactive protein kinase A active protein kinase A cellular responses Consider the homozygous mutation in which a cell produces a variant of the adrenergic receptor that is constitutively active in the absence of ligand. Which of the following are true in this cell? Select all that apply. Protein Kinase A is always activated CAMP concentration is higher than normal Heart rate decreases Heart rate increases
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