When activated extracellularly, G protein-coupled receptors (GPCRs) initiate which of the following? (select all that apply) a G protein signaling mechanism inside the cell. AG protein signaling mechanism outside the cell. Transporters to uptake degraded neurotransmitters for recyclin The release of neurotransmitter molecules into the postsynaptic

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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### Understanding G Protein-Coupled Receptors (GPCRs)

#### Question:
When activated extracellularly, G protein-coupled receptors (GPCRs) initiate which of the following? (Select all that apply)

#### Options:
- [ ] a G protein signaling mechanism inside the cell.
- [ ] A G protein signaling mechanism outside the cell.
- [ ] Transporters to uptake degraded neurotransmitters for recycling.
- [ ] The release of neurotransmitter molecules into the postsynaptic cell.

### Explanation of Terms:

**G Protein-Coupled Receptors (GPCRs):**
GPCRs are a large family of cell surface receptors that respond to a variety of external signals and activate intracellular G proteins, which in turn trigger various signaling pathways inside the cell.

**Signaling Mechanism:**
This refers to the process by which GPCRs convey the signal from the outside of the cell to the inside, usually by activating G proteins.

### Answer and Explanation:

The correct option(s) will be marked once you understand that GPCRs primarily initiate intracellular signaling mechanisms. Note that:
- GPCR activation leads to a signaling cascade inside the cell, not outside.
- GPCRs are not directly responsible for the uptake of neurotransmitters or the release of neurotransmitter molecules.

This question tests knowledge of cellular signaling pathways, specifically the role of GPCRs in initiating intracellular processes.
Transcribed Image Text:### Understanding G Protein-Coupled Receptors (GPCRs) #### Question: When activated extracellularly, G protein-coupled receptors (GPCRs) initiate which of the following? (Select all that apply) #### Options: - [ ] a G protein signaling mechanism inside the cell. - [ ] A G protein signaling mechanism outside the cell. - [ ] Transporters to uptake degraded neurotransmitters for recycling. - [ ] The release of neurotransmitter molecules into the postsynaptic cell. ### Explanation of Terms: **G Protein-Coupled Receptors (GPCRs):** GPCRs are a large family of cell surface receptors that respond to a variety of external signals and activate intracellular G proteins, which in turn trigger various signaling pathways inside the cell. **Signaling Mechanism:** This refers to the process by which GPCRs convey the signal from the outside of the cell to the inside, usually by activating G proteins. ### Answer and Explanation: The correct option(s) will be marked once you understand that GPCRs primarily initiate intracellular signaling mechanisms. Note that: - GPCR activation leads to a signaling cascade inside the cell, not outside. - GPCRs are not directly responsible for the uptake of neurotransmitters or the release of neurotransmitter molecules. This question tests knowledge of cellular signaling pathways, specifically the role of GPCRs in initiating intracellular processes.
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