How does the immune system mitigate itself to prevent the onset of autoimmune diseases? How do genetics and epigenetics play a role in the onset of autoimmune disease? What other diseases would occur co-incidently with ankylosing spondylitis, based on the mutation associated with it?
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- What is the name given toconditions in which the ownimmune system of theindividual is the agent ofdiseases? What are someexamples of these conditions?Explain the multifaceted role of interferons as first responders to viral infection: Identify important target ISGs. Discuss the general mechanisms by which interferon induced genes block virus replication.Which statement about autologous is true? Question 42 options: a) Autologous tissue should have the same shelf-life as allogeneic tissue under the same storage. b) Autologous tissue is not regulated by the AATB. c) Autologous tissue has a different outdate than aoolgeneic tissue. d) The medical director can have autologous tissue reassigned to an allogeneic donor if it is not used by the autologous donor.
- Explain the multifaceted role of interferons as first responders to viral infection: What types of interferons are activated by viruses at the earliest stages of infection? How are interferons activated? What types of stimuli activate interferons at the earliest stages of viral infection.? Identify the receptors to which interferon binds and how their activation affects gene expression?What are the roles of the following cytokines in defense against infections: 1) TNF 2) IL-12 3) Type I InterferonBriar Rose pricks her finger on a nasty - and rather dirty looking - wooden spindle, receiving a painful splinter. She decides to ignore the splinter and wrapsa bandage around her finger. The next day, Briar Rose had red streaks running up her right arm and they feel warm to the touch. A few days later she notices tender swollen bumps in her right armpit. What happened to her arm and armpit? Describe in terms of innate and adaptive immune mechanisms. Note: this is not the first time she has pricked her finger!
- What is the differencebetween humoral specificimmune response and cellularspecific immune response?Which statement about autologous is true? Question 32 options: a) The medical director can have autologous tissue reassigned to an allogeneic donor if it is not used by the autologous donor. b) Autologous tissue should have the same shelf-life as allogeneic tissue under the same storage. c) Autologous tissue is not regulated by the AATB. d) Autologous tissue has a different outdate than aoolgeneic tissue.In Lubeck, Germany, in 1930, a group of 251 infants was accidentally administered a tainted vaccine for tuberculosis that contained live Mycobacterium tuberculosis. This vaccine was administered orally, directly exposing the infants to the deadly bacterium. Many of these infants contracted tuberculosis, and some died. However, 44 of the infants never contracted tuberculosis. Based on your knowledge of the innate immune system, what innate defenses might have inhibited M. tuberculosis enough to prevent these infants from contracting the disease?
- 4) A patient has their spleen removed due to an accident. How will this affect the immune response? 5) You come in contact with staphylococci through a cut. What cellular features will the immune cells recognize? 6) Name two opsonins and how do these molecules help the immune response? 7) Fever is part of the inflammatory process. What is the role of fever during an immune response? 8) This chemical is used to induce anti-viral responses in cells to protect the cells from viral infections. 9) This complement activation pathway is activated when complement binds to an antibody bound to antigens.What are the attributes of immunoglobulins produced by multiple myeloma. Do they help the immune system? Do they cause problems?What are the immune responses to viral infections? What is the difference between epidemic and pandemic? The “Spanish Flu” in 1918 was caused by the H1N1 influenza virus. What do the “H” and “N” stand for?